Overview
Hans-Peter Kubis studied Biological Sciences with focus in Physiology at University Goettingen, Germany. He then went to Medical School Hanover, Germany and earned his doctoral degree in Biochemistry at University Hanover, followed by his habilitation in Physiology at Medical School Hanover. He worked many years investigating the regulation and development of skeletal muscle fibre types using artificial muscles in culture and animal systems. After coming to Bangor, he now works on causes and mechanisms of obesity on physiological and psychological levels, as well as on the prevention and treatment. This includes the development of weight loss strategies, techniques for investigating perceptual responses to food, analysing the interaction of nutrients and metabolism on whole body and cellular levels. Moreover, he investigates the pathophysiology of chronic diseases connected with obesity like obstructive sleep apnoea and diabetes type II. A further main interest is the investigation of mechanisms of adaptations to exercise on psychological, physiological and cellular levels. In particular, interactions of exercise stimuli and nutrients influencing skeletal muscle and whole body metabolism and weight regulation are investigated with various techniques. A broad spectrum of physiological, cellular-biochemical, as well as psychological techniques are used for the investigations. He is director of the Physical Activity and Wellbeing group (PAWB group).
Qualifications
- Habilitation in Physiology - Medical School Hanover, Germany
2004 - DSci: Dr rer nat Biochemistry - University of Hannover, Germany
1997 - Professional: Dipl. Biol. Sci. (University Goettingen, Germany)
University of Göttingen, 1991
Teaching and Supervision
I am module leader for Human Physiology and Biochemisty of Exercise modules. However, I am teaching on several other modules as well.
Research Interests
In continuation of my recent work on obesity (see publications on Research Gate) in connection with metabolism, appetite regulation and involvement of specific nutrients (i.e. sugar), we currently investigating the contribution of the autonomic nervous system (ANS) balance for appetite and craving. The ANS is the complex nervous system which is regulating bodily functions without involvement of conscious direction. Involvement and importance of the ANS balance for eating behaviour regulation is largely unknown, while the functional involvement of the parasympathetic nervous system, one major branch of the ANS, in appetite regulation is well described. ANS balance is strongly variable depending, as example, on cardiovascular fitness levels and BMI. In former work, we could show that negative energy balance of exercise is fully compensated in obese and lean females (Jackson et al. 2018), revealing that regulation of energy balance related to exercise is intact in both groups. However, our work in relation to perceptual measures of ‘wanting’ and ‘liking’ of food supports a food reward deficiency in obese people (Alabduljader et al. 2018). There are apparent discrepancies between energy balance challenges and how responses to food cues and rewards are integrated into eating behaviour. In a more lay-language explanation of this project, we will investigate why cardiovascular fit people are mostly lean and unfit people mostly overweight/obese. Indeed, the amount of calories burned by exercise is compensated in later food intake by most people; therefore, do not simply explain the difference.
In this project, with multidisciplinary collaboration under my leadership, with physiologist Dr Jonathan Moore (PAWB group, SSHES) and psychologists Dr Stephanie Baines (Psychology) and Prof. Robert Rogers (Psychology), with the PhD researcher Abdelbare Algamode (PAWB group, SSHES), we are investigating how the activation of sympathetic and parasympathetic nervous system contribute to the awareness and response to food cues in sedentary overweight/obese and highly trained lean individuals. In this work, we combine exercise and food cue trials, as well as direct stimulation of parasympathetic nervous system to understand mechanisms of appetite and craving in relation to the ANS balance. Unique technology and design of this work is expected to unravel some of the major mechanism in appetite regulation in connection with obesity and the work will contribute strongly to the field.
A further major current research project led by myself, in a longstanding collaboration with the Pulmonary Department, Ysbyty Gwynedd, including Dr Julian Owen (PAWB group, SSHES), Dr Jonathan Moore (PAWB group, SSHES), PhD researcher Claire Griffith-McGeever (PAWB group, SSHES), Dr Christopher Earing (Ysbyty Gwynedd), Consultant Dr Damian McKeon (Ysbyty Gwynedd), concerns the understanding of the causes and potential treatment of Obstructive Sleep Apnoea (OSA). OSA is a sleep disorder highly associated with obesity and has a very high cardiovascular disease risk; it leads to many problems for daily life, like severe sleepiness and fatigue, depressions etc.. OSA is very frequent in obese population, while affecting up to 6% of the adult population. In recent years, we investigated the influence of obesity related factors (inflammatory and anti-inflammatory factors - collaboration with Medical School Hanover, Department of Pharmacology) for alterations of chemosensitivity in OSA patients (Earing et al. 2019). Currently, we are investigating changes in muscular effort perception (respiratory and motoric system) in OSA patients compared with ‘healthy’ individuals. Muscle systems are differentially affected in OSA (fatigue and hyper-reactivity) and contribute substantially to the severity of symptoms in OSA. With our newly collected data, we hope to explain central and peripheral alterations in the motoric system of OSA patients and their contribution to OSA symptoms. Additionally, we collect data in ‘healthy’ participants to develop a model, which can describe and predict alterations in effort sensation and the involvement of learning processes. The mechanisms of effort sensation are still highly controversial and we expect that our model will contribute hugely to the understanding of mechanisms involved in effort sensation in health and disease (manuscript in preparation). A further project in this collaboration under my leadership is related to treatment of OSA; we currently investigating the feasibility of a remote weight-loss intervention for OSA patients for alleviating OSA symptoms via weight loss, with the support of current MRes student Rachel Granger. The intervention (Programme for Enhanced Eating Behaviour – PEEB) was formerly developed in collaboration with former PhD researcher Mishal Alshubrami and MRes student Matthew Jones (PAWB group, SSHES) (Alshubrami et al. 2017). We expect that the PEEB intervention can lead to substantial weight loss in OSA patients and will be acceptable to be implemented in the treatment scheme in the Pulmonary Department of Ysbyty Gwynedd and others in the future. This work is expected to lead to high impact and grant capture for future patients’ benefits.
Concurrently, a further important research project is now starting to investigate fatigue and effort perceptions in patients with chronic fatigue symptoms. This project is a development based on my former projects with OSA patients but now focusing on further patient groups with major fatigue symptoms. Chronic fatigue is often a major symptom in particular patients groups (RA, OSA, Chronic Fatigue Syndrome, Cancer, etc.) and there is very little treatment available, as well as the understanding of the mechanisms involved is lacking. Based on our effort perception data with OSA and healthy patients, we hypothesize that learning processes play an important role for fatigue symptoms, if physiological reasons are not apparent, like in rheumatoid arthritis (RA) patients with controlled inflammation. We will use our effort perception testing paradigm (manuscript in preparation), developed for OSA patients, to investigate effort and fatigue perception and prediction, moreover, we will adopt our recently established evaluative conditioning protocol (see below) in connection with exercise for influencing effort and fatigue perception in RA patients with major fatigue symptoms. Patients will take part in exercise training programmes, known to alleviate fatigue symptoms, but will be additionally conditioned with associated rewarding stimuli (sweet solutions) during increased physiological loading. A bespoke computer software has been developed by us using heart rate data in connection with a dual syringe system to deliver sweet rewards to participants’ oral cavity depending on the level of heart rate. The project will be performed in multidisciplinary collaboration with Dr Stephanie Baines (Psychology), Dr Jeremy Jones (Peter Maddison Centre, Ysbyty Gwynedd), together with a new PhD researcher (Saleh Elmsmari, PAWB group, SSHES) under my lead. This project aims to influence effort and fatigue perception, to gain better understanding of the mechanisms in chronic fatigue and to treat chronic fatigue.
A further research project under my lead is investigating the perception of exercise in various population groups. Physical activity is commonly very low in industrialized societies with severe negative outcomes for health risks. However, whether exercise is perceived as a reward and whether valuation of exercise can be influenced has not been established. In multidisciplinary collaboration with Prof Robert Rogers (Psychology) and with PhD researcher Tamam Albelwi (PAWB group, SSHES), we use discounting paradigms to measure reward decays of money, exercise and food to understand exercise valuation and factors influencing choices for the health behaviour exercise (motivation, context etc.) (Albelwi et al. 2019). The current project includes also online surveys, where exercise discounting and the involved motives for exercise are investigated in various population groups. Furthermore, we developed a new conditioning paradigm to use sweet rewards, which are linked with the appearance of cardiovascular strain (heart rate) during exercise training, for performing evaluative conditioning. This project aims to influence peoples’ choices towards higher intensities in exercise and to understand choice processes involved in exercise behaviour. Sedentary population tend to choose exercise intensities below the threshold needed for physiological adaptation. Influencing choice behaviour towards higher intensities would increase health benefits of self-selected physical activity for this population group. Currently, additional data are collected to investigate whether the conditioning effects also transfer to performance trials in athletic population. Based on the substantial effects of the conditioning we observed in this project, we also implement the protocol in a research project focusing on effort and fatigue processes (see above).
Postgraduate Project Opportunities
Potential PhD students can contact me regarding following topics:
1. Influence of exercise and physical activity on appetite regulation.
2. Fatigue and effort perception in health and disease.
3. Exercise perception and its valuation in various clinical and healthy populations.
4. Obesity and its consequences for physiological and psychological responses to exercise and food intake.
Publications
2024
- PublishedA retrospective comparison of the biceps femoris long head muscle structure in athletes with and without hamstring strain injury history
Yagiz, G., Fredianto, M., Ulfa, M., Aiani, I., Shida, N., Moore, E. W. G. & Kubis, H.-P., 26 Feb 2024, In: PLoS ONE. 19, 2, p. e0298146 19 p., e0298146.
Research output: Contribution to journal › Article › peer-review - PublishedThe influence of low resistance respiratory muscle training on pulmonary function and high intensity exercise performance
Kubis, H.-P., Sartor, F. & Al-Otaibi, H., Jul 2024, In: Journal of Exercise Science and Fitness. 22, 3, p. 179-186 8 p.
Research output: Contribution to journal › Article › peer-review
2023
- PublishedDifferential effects of repeated inspiratory and limb muscle loading on effort perception in patients with obstructive sleep apnea and healthy males
Griffith-McGeever, C. L., Owen, J., Earing, C., McKeon, D. & Kubis, H.-P., Jun 2023, In: Psychological Reports. 11, 11, 18 p., e15732.
Research output: Contribution to journal › Article › peer-review - PublishedInfluence of motor imagery training on hip abductor muscle strength and bilateral transfer effect
Alenezi, M., Hayes, A., Lawrence, G. & Kubis, H.-P., 7 Sept 2023, In: Frontiers in Physiolology. Section: Exercise Physiology. 14, 16 p., 1188658.
Research output: Contribution to journal › Article › peer-review - PublishedRugby Players Exhibit Stiffer Biceps Femoris, Lower Biceps Femoris Fascicle Length to Knee Extensors, and Knee Flexors to Extensors Muscle Volume Ratios Than Active Controls
Yagiz, G., Shida, N., Kuruma, H., Furuta, M., Morimoto, K., Yamada, M., Uchiyama, T., Kubis, H.-P. & Owen, J., Sept 2023, In: International Journal of Sports Physiology and Performance. 18, 9, p. 1030-1037
Research output: Contribution to journal › Article › peer-review - PublishedToo much is too much: Influence of former stress levels on food craving and weight gain during the COVID-19 period
Granger, R. & Kubis, H.-P., 27 Apr 2023, In: PLoS ONE. 18, 4, p. e0277856 18 p., 0277856.
Research output: Contribution to journal › Article › peer-review - PublishedWomen’s experiences of social support during pregnancy: a qualitative systematic review
Almutawtah, M. E. A. A. H., Campbell, E., Kubis, H.-P. & Erjavec, M., 10 Nov 2023, In: BMC Pregnancy and Childbirth. 23, 1, 19 p., 782.
Research output: Contribution to journal › Article › peer-review
2022
- PublishedAlterations in biceps femoris long head fascicle length, eccentric hamstring strength qualities and single-leg hop distance throughout the ninety minutes of TSAFT90 simulated football match
Yagiz, G., Williams, K., Owen, J. & Kubis, H.-P., 9 Dec 2022, In: PLoS ONE. 17, 12, p. e0278222 22 p., e0278222.
Research output: Contribution to journal › Article › peer-review - PublishedThe Effects of Resistance Training on Architecture and Volume of the Upper Extremity Muscles: A Systematic Review of Randomised Controlled Trials and Meta-Analyses
Yagiz, G., Akaras, E., Kubis, H.-P. & Owen, J. A., 2 Feb 2022, In: Applied Sciences. 12, 3, 21 p., 1593.
Research output: Contribution to journal › Article › peer-review - PublishedToo much is too much: influence of former stress levels on food craving and weight gain during the COVID-19 period
Granger, R. & Kubis, H.-P., 8 Nov 2022, (MedRxiv).
Research output: Working paper › Preprint
2021
- PublishedCarrots for the donkey: Influence of evaluative conditioning and training on self-paced exercise intensity and delay discounting of exercise in healthy adults
Kubis, H.-P., Albelwi, T. & Rogers, R., 6 Oct 2021, In: PLoS ONE. 16, 10, 25 p., e0257953.
Research output: Contribution to journal › Article › peer-review - PublishedHeterogeneous effects of eccentric training and nordic hamstring exercise on the biceps femoris fascicle length based on ultrasound assessment and extrapolation methods: A systematic review of randomised controlled trials with meta-analyses
Yagiz, G., Akaras, E., Kubis, H.-P. & Owen, J. A., 9 Nov 2021, In: PLoS ONE. 16, 11, 23 p., e0259821.
Research output: Contribution to journal › Article › peer-review - PublishedPlasma Interleukin-10 and Cholesterol Levels May Inform about Interdependences between Fitness and Fatness in Healthy Individuals
Sartor, F., Moore, J. & Kubis, H.-P., 12 Feb 2021, In: International Journal of Environmental Research and Public Health. 18, 4, 1800.
Research output: Contribution to journal › Article › peer-review
2019
- PublishedAn act of balance: interaction of central and peripheral chemosensitivity with inflammatory and anti-inflammatory factors in obstructive sleep apnoea
Earing, C., Owen, J., Griffith-Mcgeever, C., McKeon, D., Engeli, S., Moore, J. & Kubis, H.-P., Aug 2019, In: Respiratory Physiology & Neurobiology. 266, p. 73-81
Research output: Contribution to journal › Article › peer-review - PublishedExercise as a reward: Self-paced exercise perception and delay discounting in comparison with food and money
Albelwi, T., Rogers, R. & Kubis, H.-P., 1 Feb 2019, In: Physiology and Behavior. 199, p. 333-342
Research output: Contribution to journal › Article › peer-review - PublishedQuarter-mile walk test sensitive to training-induced fitness changes
Papini, G., Carder, C., Lightfoot, C. J., Kubis, H.-P. & Bonomi, A. G., Nov 2019, In: Journal of Sports Medicine and Physical Fitness. 59, 11, p. 1820-7
Research output: Contribution to journal › Article › peer-review - PublishedThe Effects of Beetroot Juice on Blood Pressure, Microvascular Function and Large-Vessel Endothelial Function: A Randomized, Double-Blind, Placebo-Controlled Pilot Study in Healthy Older Adults.
Jones, T., Dunn, E., Macdonald, J., Kubis, H.-P., McMahon, N. & Sandoo, A., 2 Aug 2019, In: Nutrients. 11, 8, p. 1792
Research output: Contribution to journal › Article › peer-review
2018
- PublishedDeterminants of apnoea –hypopnoea-index (AHI) levels in newly diagnosed obstructive sleep apnoea patients
Owen, J., Earing, C., Griffith-Mcgeever, C., McKeon, D., Engeli, S., Moore, J. & Kubis, H.-P., Sept 2018.
Research output: Contribution to conference › Poster › peer-review - PublishedEcological momentary assessment of food perceptions and eating behavior using a novel phone application in adults with or without obesity
Alabduljader, K., Cliffe, M., Sartor, F., Papini, G., Cox, W. M. & Kubis, H.-P., Aug 2018, In: Eating Behaviors. 30, August, p. 35-41
Research output: Contribution to journal › Article › peer-review - PublishedExercise training and weight loss, not always a happy marriage: single blind exercise trials in females with diverse BMI
Jackson, M., Fatahi, F., Alabduljader, K., Jelleyman, C., Moore, J. & Kubis, H.-P., Apr 2018, In: Applied Physiology, Nutrition, and Metabolism. 43, 4, p. 363-370
Research output: Contribution to journal › Article › peer-review
2017
- PublishedConceptualization of physical exercise and keeping fit by child wheelchair users and their parents
Noyes, J., Spencer, L. H., Bray, N., Kubis, H.-P., Hastings, R. P., Jackson, M. & O'Brien, T. D., May 2017, In: Journal of Advanced Nursing. 73, 5, p. 1111-1123 13 p.
Research output: Contribution to journal › Article › peer-review - PublishedEffectiveness of a weight-loss intervention using selfmonitoring practice with eating behavioral commandments in obese females
Alshubrami, M., Alrajhi, S., Cox, W. M. & Kubis, H.-P., 2017, In: Saudi Journal of Obesity. 5, 2, p. 77-84
Research output: Contribution to journal › Article › peer-review
2016
- PublishedA 45-Second Self-Test for Cardiorespiratory Fitness: Heart Rate-Based Estimation in Healthy Individuals
Sartor, F., Bonato, M., Papini, G., Bosio, A., Mohammed, R. A., Bonomi, A. G., Moore, J., Merati, G., La Torre, A. & Kubis, H.-P., 13 Dec 2016, In: PLoS ONE. 11, 12, e0168154.
Research output: Contribution to journal › Article › peer-review - PublishedPrimary skeletal muscle cells cultured on gelatin bead microcarriers develop structural and biochemical features characteristic of adult skeletal muscle
Kubis, H., Kubis, H. P., Scheibe, R. J., Decker, B., Hufendiek, K., Hanke, N., Gros, G. & Meissner, J. D., 20 Jan 2016, In: Cell Biology International.
Research output: Contribution to journal › Article › peer-review - PublishedSystematic review of physical activity and exercise interventions to improve health, fitness and well-being of children and young people who use wheelchairs
O'Brien, T. D., Noyes, J., Spencer, L. H., Kubis, H.-P., Hastings, R. P. & Whitaker, R., 15 Nov 2016, In: BMJ Open Sport & Exercise Medicine. 2, 1, e000109.
Research output: Contribution to journal › Article › peer-review
2015
- PublishedComparison between moderate-high exercise and continuous exercise in a real-life cardiac rehabilitation setting - nine months follow-up
Kubis, H., Pernick, Y., Zyssman, I., Kubis, H. P., Moore, J. P. & Vered, Z., 1 Aug 2015, In: European Heart Journal. 36, 1, p. 633
Research output: Contribution to journal › Article › peer-review
2014
- Published'Keep fit' exercise interventions to improve health, fitness and well-being of children and young people who use wheelchairs: mixed-method systematic review protocol.
O'Brien, T. D., Noyes, J., Spencer, L. H., Kubis, H., Hastings, R. P., Edwards, R. T., Bray, N. & Whitaker, R., 18 May 2014, In: Journal of Advanced Nursing. 70, 12, p. 2942-2951
Research output: Contribution to journal › Article › peer-review - PublishedDivers revisited: The ventilatory response to carbon dioxide in experienced scuba divers
Kubis, H., Earing, C. M., McKeon, D. J. & Kubis, H. P., 20 Feb 2014, In: Respiratory Medicine. 108, 5, p. 758-765
Research output: Contribution to journal › Article › peer-review - PublishedWell-being, health and fitness of children who use wheelchairs: Feasibility study protocol to develop child-centred ‘keep-fit’ exercise interventions
OBrien, T. D., Kubis, H., Bray, N. J., O'Brien, T. D., Noyes, J., Spencer, L. H., Kubis, H. P., Edwards, R. T., Bray, N. & Whitaker, R., 24 Jul 2014, In: Journal of Advanced Nursing. 71, 2, p. 430-440
Research output: Contribution to journal › Article › peer-review
2013
- PublishedAdaptive metabolic response to 4 weeks of sugar-sweetened beverage consumption in healthy, lightly active individuals and chronic high glucose availability in primary human myotubes
Kubis, H., Sartor, F., Jackson, M. J., Squillace, C., Shepherd, A., Moore, J. P., Ayer, D. E. & Kubis, H. P., 1 Apr 2013, In: European Journal of Nutrition. 52, 3, p. 937-948
Research output: Contribution to journal › Article › peer-review - PublishedEstimation of Maximal Oxygen Uptake via Submaximal Exercise Testing in Sports, Clinical, and Home Settings
Kubis, H., Sartor, F., Vernillo, G., De Morree, H. M., Bonomi, A. G., La Torre, A., Kubis, H. P. & Veicsteinas, A., 13 Jul 2013, In: Sports Medicine. 43, 9, p. 865-873
Research output: Contribution to journal › Article › peer-review
2011
- PublishedGene regulation mediating fiber-type transformation in skeletal muscle cells is partly glucose- and ChREBP-dependent.
Hanke, N., Scheibe, R. J., Manukjan, G., Ewers, D., Umeda, P. K., Chang, K. C., Kubis, H., Gros, G. & Meissner, J. D., 1 Mar 2011, In: Biochimica et Biophysica Acta - Molecular Cell Research. 1813, 3, p. 377-389
Research output: Contribution to journal › Article › peer-review - PublishedTaste perception and implicit attitude toward sweet related to body mass index and soft drink supplementation
Markland, D. A., Kubis, H., Sartor, F., Donaldson, L. F., Markland, D., Loveday, H., Jackson, M. J. & Kubis, H. P., 1 Aug 2011, In: Appetite. 57, 1, p. 237-246
Research output: Contribution to journal › Article › peer-review
2010
- PublishedHigh-intensity exercise and carbohydrate-reduced energy-restricted diet in obese individuals.
Kubis, H., Sartor, F., De Morree, H., Matschke, V., Marcora, S. M., Milousis, A., Thom, J. M. & Kubis, H. P., 14 Jul 2010, In: European Journal of Applied Physiology. 110, 5, p. 893-903
Research output: Contribution to journal › Article › peer-review - PublishedInfluence of a four week energy drink intervention on glucose homeostatis in healthy sedentary individuals.
Kubis, H., Sartor, F., Jackson, M. & Kubis, H. P., 27 Mar 2010.
Research output: Contribution to conference › Paper - PublishedPassive mechanical forces act via integrin and p38 mitogen-activated protein kinase to increase the expression of myosin heavy chain IId in primary skeletal muscle cells in culture.
Kubis, H., Hanke, N., Kubis, H. P., Scheibe, R. J., Berthold-Losleben, M., Husing, O., Meissner, J. D. & Gros, G., 27 Mar 2010.
Research output: Contribution to conference › Paper - PublishedPassive mechanical forces upregulate the fast myosin heavy chain IId/x via integrin and p38 MAP-Kinase activation in a primary muscle cell culture.
Hanke, N., Kubis, H., Scheibe, R. J., Berthold-Losleben, M., Huesing, O., Meissner, J. D. & Gros, G., 13 Jan 2010, In: American Journal of Physiology - Cell Physiology. 298, p. C910-C920
Research output: Contribution to journal › Article › peer-review
2009
- PublishedCombination of a low-carbohydrate diet with high intensity interval training on insulin sensitivity, blood lipids and whole body metabolism in obese sedentary individuals.
Kubis, H., Sartor, F., De Morree, H., Marcora, S. M., Matschke, V., Thom, J. M. & Kubis, H. P., 1 Jan 2009.
Research output: Contribution to conference › Paper - PublishedDifferent roles of H-ras for regulation of myosin heavy chain promoters in satellite cell derived muscle cell culture during proliferation and differentiation.
Scholz, M. E., Meissner, J. D., Scheibe, R. J., Umeda, P. K., Chang, K. C., Gros, G. & Kubis, H., 22 Jul 2009, In: American Journal of Physiology - Cell Physiology. 297, p. C1012-C1018
Research output: Contribution to journal › Article › peer-review - PublishedExercise and cellular adaptation of muscle.
Kubis, H., Tegtbur, U., Busse, M. W. & Kubis, H. P., 1 Apr 2009, In: Unfallchirurg. 112, 4, p. 365-372
Research output: Contribution to journal › Article › peer-review - PublishedMorphological characterization of skeletal muscle cells grown on microcarriers.
Kubis, H., Squillace, C., Salucci, S., Battistelli, M., Burattini, S., Sartor, F., Kubis, H. P. & Falcieri, E., 1 Jan 2009.
Research output: Contribution to conference › Paper
2008
- PublishedLow glucose availability induces metabolic transformation of primary rabbit muscle cells in culture.
Kubis, H., Kubis, H. P., Meissner, J. D., Scheibe, R. J., Endeward, V., Gros, G. & Hanke, N., 1 Jan 2008.
Research output: Contribution to conference › Paper - PublishedMetabolic transformation of rabbit skeletal muscle cells in primary culture in response to low glucose.
Hanke, N., Meissner, J. D., Scheibe, R. J., Endeward, V., Gros, G. & Kubis, H., 1 May 2008, In: Biochimica et Biophysica Acta - Molecular Cell Research. 1783, 5, p. 813-825
Research output: Contribution to journal › Article › peer-review
2007
- PublishedThe p38 alpha/beta mitogen-activated protein kinases mediate recruitment of CREB-binding protein to preserve fast myosin heavy chain IId/x gene activity in myotubes.
Kubis, H., Meissner, J. D., Chang, K. C., Kubis, H. P., Nebreda, A. R., Gros, G. & Scheibe, R. J., 9 Mar 2007, In: Journal of Biological Chemistry. 282, 10, p. 7265-7275
Research output: Contribution to journal › Article › peer-review
2006
- PublishedContractile properties of skeletal muscle fibre bundles from mice deficient in carbonic anhydrase II.
Kubis, H., Beekley, M. D., Wetzel, P., Kubis, H. P. & Gros, G., 1 Jul 2006, In: Pflugers Archiv - European Journal of Physiology. 452, 4, p. 453-463
Research output: Contribution to journal › Article › peer-review
2005
- PublishedAccumulation and nuclear import of HIF1 alpha during high and low oxygen concentration in skeletal muscle cells in primary culture.
Kubis, H., Kubis, H. P., Hanke, N., Scheibe, R. J. & Gros, G., 1 Sept 2005, In: Biochimica et Biophysica Acta - Molecular Cell Research. 1745, 2, p. 187-195
Research output: Contribution to journal › Article › peer-review - PublishedHypertrophic cardiomyopathy-related beta-myosin mutations cause highly variable calcium sensitivity with functional imbalances among individual muscle cells.
Kubis, H., Kirschner, S. E., Becker, E., Antognozzi, M., Kubis, H. P., Francino, A., Navarro-Lopez, F., Bit-Avragim, N., Perrot, A., Mirrakhimov, M. M., Osterziel, K. J., McKenna, W. J., Brenner, B. & Kraft, T., 1 Mar 2005, In: American Journal of Physiology - Heart and Circulatory Physiology. 288, 3, p. H1242-H1251
Research output: Contribution to journal › Article › peer-review
2003
- PublishedCa2+ transients activate calcineurin/NFATc1 and initiate fast-to-slow transformation in a primary skeletal muscle culture.
Kubis, H., Kubis, H. P., Hanke, N., Scheibe, R. J., Meissner, J. D. & Gros, G., 1 Jul 2003, In: American Journal of Physiology - Cell Physiology. 285, 1, p. C56-C63
Research output: Contribution to journal › Article › peer-review
2002
- PublishedFast-to-slow transformation and nuclear import/export kinetics of NFATc1 during electrostimulation of muscle cells in culture.
Kubis, H., Kubis, H. P., Scheibe, R. J., Meissner, J. D., Hornung, G. & Gros, G., 1 Jan 2002, In: Journal of Physiology. 541, 3, p. 835-847
Research output: Contribution to journal › Article › peer-review - PublishedIn vitro engineering of heart muscle: artificial myocardial tissue.
Kubis, H., Kofidis, T., Akhyari, P., Boublik, J., Theodorou, P., Martin, U., Ruhparwar, A., Fischer, S., Eschenhagen, T., Kubis, H. P., Kraft, T., Leyh, R. & Haverich, A., 1 Jul 2002, In: Journal of Thoracic and Cardiovascular Surgery. 124, 1, p. 63-69
Research output: Contribution to journal › Article › peer-review
2001
- PublishedCalcineurin regulates slow myosin, but not fast myosin or metabolic enzymes, during fast-to-slow transformation in rabbit skeletal muscle cell culture.
Kubis, H., Meissner, J. D., Gros, G., Scheibe, R. J., Scholz, M. & Kubis, H. P., 1 May 2001, In: Journal of Physiology. 533, 1, p. 215-226
Research output: Contribution to journal › Article › peer-review
2000
- PublishedImmunochemical evidence for a unique GPI-anchored Carbonic anhydrase isozyme in human cardiomyocytes.
Kubis, H., Knuppel-Ruppert, A. S., Gros, G., Harringer, W. & Kubis, H. P., 1 Apr 2000, In: American Journal of Physiology - Heart and Circulatory Physiology. 278, 4, p. H1335-H1344
Research output: Contribution to journal › Article › peer-review - PublishedProperties of a carbonic anhydrase inhibitor protein in flounder serum.
Kubis, H., Peters, T., Papadopoulos, F., Kubis, H. P. & Gros, G., 1 Oct 2000, In: Journal of Experimental Biology. 203, 19, p. 3003-3009
Research output: Contribution to journal › Article › peer-review - PublishedReversible Ca2+ -induced fast-to-slow transition in primary skeletal muscle culture cells at the mRNA level
Kubis, H., Meissner, J. D., Kubis, H. P., Scheibe, R. J. & Gros, G., 15 Feb 2000, In: Journal of Physiology. 523, 1, p. 19-28
Research output: Contribution to journal › Article › peer-review
1999
- PublishedContraction parameters, myosin composition and metabolic enzymes of the skeletal muscles of the etruscan shrew Suncus etruscus and of the common european white-toothed shrew Crocidura russula (Insectivora: soricidae)
Peters, T., Kubis, H. P., Wetzel, P., Sender, S., Asmussen, G., Fons, R. & Jürgens, K. D., 15 Sept 1999, In: Journal of Experimental Biology. 202, 18, p. 2461-2473 13 p.
Research output: Contribution to journal › Article › peer-review
1998
- PublishedRenal tubular acidosis in a Frisian stallion caused by carbonic anhydrase deficiency
Brandt, K., Swagemakers, J. H., Bickhardt, K., Kubis, H. P., Gross, G. & Deegen, E., 1998, In: Equine Veterinary Education. 10, 5, p. 250-254 5 p.
Research output: Contribution to journal › Article › peer-review
1997
- PublishedA rapid electrophoretic method for separating rabbit skeletal muscle myosin heavy chains at high resolution
Kubis, H.-P. & Gros, G., 1997, In: ELECTROPHORESIS. 18, 1, p. 64-66 3 p.
Research output: Contribution to journal › Article › peer-review - PublishedAdult fast myosin pattern and Ca2+-induced slow myosin pattern in primary skeletal muscle culture
Kubis, H.-P., Haller, E.-A., Wetzel, P. & Gros, G., 15 Apr 1997, In: Proceedings of the National Academy of Sciences of the United States of America. 94, 8, p. 4205-4210
Research output: Contribution to journal › Article › peer-review
1992
- PublishedEffects of 1,2-dihydro-4-hydroxy-6-methoxy-N-methyl quinoline in relation to circadian rhythms of NAD+ kinase and NADP+ autoreduction in Neurospora crassa and bioluminescence in Gonyaulax polyedra
Kubis, H.-P., Balzer, I. & Hardeland, R., May 1992, In: Comparative Biochemistry and Physiology Part C: Comparative Pharmacology. 102, 1, p. 97-101 5 p.
Research output: Contribution to journal › Article › peer-review
Activities
2022
- BU-IIA Funded Project: Preparation for an application of a feasibility trial for Oro-sensory exercise training for patients with chronic fatigue symptoms
Fatigue is a common symptom associated with many medical conditions like obstructive sleep apnoea (OSA), rheumatoid arthritis (RA), and COVID 19, i.e., long COVID. Fatigue manifests itself in the form of exhaustion and tiredness. Indeed, fatigue has a profound impact on sufferers’ quality of life, while treatment schemes are limited and focusing mainly on graded exercise training (GET). Exercise treatment, however, does not recognize potential problems with effort-reward imbalance in fatigue patients affecting motivation for investing effort in tasks. Recently, we have investigated the influence of evaluative conditioning using a novel technique on self-selected exercise intensity and effort sensation in healthy sedentary individuals (Kubis et al. 2021; https://doi.org/10.1371/journal.pone.0257953). Outcomes show that individuals self-select exercise intensity significantly higher than control individuals after the conditioning training even weeks after the training. Analyses revealed that the intensity of exercise selected was a function of integrated reward over effort costs. This opens the opportunity to use this type of training for patients with fatigue conditions, conditioned reward (based on our Oro-sensory exercise training) would potentially enable patients to improve their effort-reward imbalance enabling them to increase the intensity of daily activities and reduce fatigue symptoms. Conclusively, our grant application uses funds for bespoke equipment and testing of portable systems which can be used in exercise rehabilitation settings as well as for developing/writing a grant application for a proof of concept / feasibility trial.
Funding awarded through the Bangor University Innovation and Impact Award (Research Wales Innovation Funding). Value = £6947
1 Apr 2022 – 31 Mar 2023
Activity: Other (Contributor)
Projects
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Low Carbohydrate Diet Comined With
01/02/2008 – 31/07/2009 (Finished)