2024

2023

2022

  • PublishedCyclic guanidine containing amino acids that promote glucocerebrosidase
    Al-Taie, Z. S., Bartholomew, B., Coles, S. J., Evans, D. M., Hollinshead, J., Jones, L. F., Kraehenbuehl, R., Murphy, P. J., Nash, R. J., Penkova, Y. B. & Tizzard, G. J., 24 Sept 2022, In: Tetrahedron. 123, 132959.
    Research output: Contribution to journal › Article › peer-review
  • PublishedSynthesis of (+)-(R)-Tiruchanduramine
    Al-Taie, Z. S., Bartholomew, B., Cartmell, C., Froom, R., Kerr, R. G., Kraehenbuehl, R., Murphy, P., Nash, R. J., Penkova, Y. B. & van Teijlingen, A., 16 Feb 2022, In: Molecules. 27, 4
    Research output: Contribution to journal › Article › peer-review

2020

2015

2011

2009

  • PublishedFlipping of alkylated DNA damage bridges base and nucleotide excision repair
    Tubbs, J. L., Latypov, V., Kanugula, S., Butt, A., Melikishvili, M., Kraehenbuehl, R., Fleck, O., Marriott, A., Watson, A. J., Verbeek, B., McGown, G., Thorncroft, M., Santibanez-Koref, M. F., Millington, C., Arvai, A. S., Kroeger, M. D., Peterson, L. A., Williams, D. M., Fried, M. G., Margison, G. P., Pegg, A. E. & Tainer, J. A., 11 Jun 2009, In: Nature. 459, p. 808-813
    Research output: Contribution to journal › Article › peer-review

2008

2006

2004

1995

2022

  • BU-IIA Funded Project: A step towards sustainable farming and nutritional health - Metabolomic characterisation of low phytic acid barley

    Food production would be more sustainable if crops were more phosphorous-efficient. This would reduce fertilizer use and consequently nutrient leaching from farms and eutrophication of water bodies. Phosphate partitioning in the crop is a complex and little-understood trait. Prior research at Bangor has identified a unique set of barley lines that need less phosphate fertiliser than normal crops. They have lower levels of phytic acid (PA) stored in the grains but no significant yield penalty. By comparing their metabolite profiles with those of normal barley we can gain understanding of how lower PA influences both grain production and human nutritional value (reduced PA in the diet can aid gut absorption of iron). The metabolomics data produced from the project will feed into prototype machine learning and multi-omics network models being developed at Teeside University. This will lead to deeper knowledge of the mechanisms and biological processes involved. The goal is to broaden the scientific evidence base and work with relevant stakeholders to invest in low PA crop development. This could ultimately lead to more sustainable crops and wider availability of healthy wholegrains, benefiting not only economies and societies in the western world but also in developing countries.

    Funding awarded through the Bangor University Innovation and Impact Award (Research Wales Innovation Funding). Value = £34,926

    1 Apr 2022 – 31 Mar 2023

    Activity: Other (Contributor)
  • BU-IIA Funded Project: Genotoxicity of nucleoside analogue anti-viral and anti-cancer drugs

    The overall aim of the proposed research is to optimise and apply the range of assays we have developed to assess the genotoxic impact of some key anti-cancer (Gemcitabine) and anti-viral (Remdesivir and Molnupiravir) nucleoside analogues and publish this analysis as proof of principle and advertise the knowledge and expertise we have developed here in Wales. The proposed research involves a new collaboration between Bangor applicants and the recently established company Broken String Biosciences Ltd., which offers assays that are complementary to the assays we have been developing. In the long term, we believe there is significant potential for impact and commercial exploitation of our assays, e.g. by influencing requirements for genotoxic assessment of nucleoside analogue drugs and offering our expertise and novel assays as a commercial service for pharmaceutical companies to assess the on- and off-target effects of candidate nucleoside analogue drugs.

    Funding awarded through the Bangor University Innovation and Impact Award (Research Wales Innovation Funding). Value = £45,942

    1 Apr 2022 – 31 Mar 2023

    Activity: Other (Contributor)