2024

• CyhoeddwydC2-Symmetric Amino Acid Amide-Derived Organocatalysts
  Al-Taie, Z., Coles, S. J., Horton, P., Kraehenbuehl, R., Murphy, P. & Tizzard, G., 24 Awst 2024, Yn: Reactions. 5, 3, t. 567-586
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2023

• CyhoeddwydModified Hederagenin Derivatives Demonstrate Ex Vivo Anthelmintic Activity against Fasciola hepatica
  Chakroborty, A., Pritchard, D., Bouillon, M., Cervi, A., Kraehenbuehl, R., Wild, C., Fenn, C., Holdsworth, P., Capner, C., Padalino, G., Forde-Thomas, J. E., Payne, J., Smith, B. G. & Hoffmann, K., 3 Gorff 2023, Yn: Pharmaceutics. 15, 7, 1869.
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2022

• CyhoeddwydCyclic guanidine containing amino acids that promote glucocerebrosidase
  Al-Taie, Z. S., Bartholomew, B., Coles, S. J., Evans, D. M., Hollinshead, J., Jones, L. F., Kraehenbuehl, R., Murphy, P. J., Nash, R. J., Penkova, Y. B. & Tizzard, G. J., 24 Medi 2022, Yn: Tetrahedron. 123, 132959.
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
• CyhoeddwydSynthesis of (+)-(R)-Tiruchanduramine
  Al-Taie, Z. S., Bartholomew, B., Cartmell, C., Froom, R., Kerr, R. G., Kraehenbuehl, R., Murphy, P., Nash, R. J., Penkova, Y. B. & van Teijlingen, A., 16 Chwef 2022, Yn: Molecules. 27, 4
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2020

• CyhoeddwydMre11 exonuclease activity removes the chain-terminating nucleoside analog gemcitabine from the nascent strand during DNA replication
  Böckemeier, L., Kraehenbuehl, R., Keszthelyi, A., Gasasira, M. U., Vernon, E., Beardmore, R., Broberg Vågbø, C., Chaplin, D., Collins, S., Krokan, H. E., Lambert, S. A. E., Paisz, B. & Hartsuiker, E., 29 Mai 2020, Yn: Science Advances. 6, 22, 9 t., eaaz4126.
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2015

• CyhoeddwydIdentification of a Class of Protein ADP-Ribosylating Sirtuins in Microbial Pathogens
  Rack, J. G. M., Morra, R., Barkauskaite, E., Kraehenbuehl, R., Ariza, A., Qu, Y., Ortmayer, M., Leidecker, O., Cameron, D. R., Matic, I., Peleg, A. Y., Leys, D., Traven, A. & Ahel, I., 16 Gorff 2015, Yn: Molecular Cell. 59, 2, t. 309-20 12 t.
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
• CyhoeddwydUV induced ubiquitination of the yeast Rad4-Rad23 complex promotes survival by regulating cellular dNTP pools
  Zhou, Z., Humphryes, N., van Eijk, P., Waters, R., Yu, S. R., Kraehenbuehl, R., Hartsuiker, E. & Reed, S. H., 6 Gorff 2015, Yn: Nucleic Acids Research. 43, 15, t. 7360-7370
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2011

• CyhoeddwydDNA Repair Factor APLF Is a Histone Chaperone
  Kraehenbuehl, R., 2011, Yn: Molecular Cell. 41
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
• CyhoeddwydIdentification of Macrodomain Proteins as NovelO-Acetyl-ADP-ribose Deacetylases
  Kraehenbuehl, R., 2011, Yn: Journal of Biological Chemistry.
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
• CyhoeddwydStructure of an aprataxin neurodegenerative disease
  Kraehenbuehl, R., 2011, Yn: Nature Structural Molecular Biology.
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2009

• CyhoeddwydFlipping of alkylated DNA damage bridges base and nucleotide excision repair
  Tubbs, J. L., Latypov, V., Kanugula, S., Butt, A., Melikishvili, M., Kraehenbuehl, R., Fleck, O., Marriott, A., Watson, A. J., Verbeek, B., McGown, G., Thorncroft, M., Santibanez-Koref, M. F., Millington, C., Arvai, A. S., Kroeger, M. D., Peterson, L. A., Williams, D. M., Fried, M. G., Margison, G. P., Pegg, A. E. & Tainer, J. A., 11 Meh 2009, Yn: Nature. 459, t. 808-813
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2008

• CyhoeddwydFunctionally distinct nucleosome-free regions in yeast require Rad7 and Rad16 for nucleotide excision repair
  Kraehenbuehl, R., 2008, Yn: DNA Repair. 7, 5
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2006

• CyhoeddwydGenetic diversity and pathogenicity of the grass pathogen Xanthomonas translucens pv. graminis
  Kraehenbuehl, R., 2006, Yn: Systematic and Applied Microbiology. 29, 2
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2004

• CyhoeddwydGenetic and cytological characterization of the RecA-homologous proteins Rad51 and Dmc1 of Schizosaccharomyces pombe
  Kraehenbuehl, R., 2004, Yn: Current Genetics. 44
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

1995

• CyhoeddwydDefinition of constitutive gene expression in plants: the translation initiation factor 4A gene as a model
  Kraehenbuehl, R., 1995, Yn: Plant Molecular Biology.
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2022

• BU-IIA Funded Project: A step towards sustainable farming and nutritional health - Metabolomic characterisation of low phytic acid barley

  Food production would be more sustainable if crops were more phosphorous-efficient. This would reduce fertilizer use and consequently nutrient leaching from farms and eutrophication of water bodies. Phosphate partitioning in the crop is a complex and little-understood trait. Prior research at Bangor has identified a unique set of barley lines that need less phosphate fertiliser than normal crops. They have lower levels of phytic acid (PA) stored in the grains but no significant yield penalty. By comparing their metabolite profiles with those of normal barley we can gain understanding of how lower PA influences both grain production and human nutritional value (reduced PA in the diet can aid gut absorption of iron). The metabolomics data produced from the project will feed into prototype machine learning and multi-omics network models being developed at Teeside University. This will lead to deeper knowledge of the mechanisms and biological processes involved. The goal is to broaden the scientific evidence base and work with relevant stakeholders to invest in low PA crop development. This could ultimately lead to more sustainable crops and wider availability of healthy wholegrains, benefiting not only economies and societies in the western world but also in developing countries.

  Funding awarded through the Bangor University Innovation and Impact Award (Research Wales Innovation Funding). Value = £34,926

  1 Ebr 2022 – 31 Maw 2023

  Gweithgaredd: Arall (Cyfrannwr)
• BU-IIA Funded Project: Genotoxicity of nucleoside analogue anti-viral and anti-cancer drugs

  The overall aim of the proposed research is to optimise and apply the range of assays we have developed to assess the genotoxic impact of some key anti-cancer (Gemcitabine) and anti-viral (Remdesivir and Molnupiravir) nucleoside analogues and publish this analysis as proof of principle and advertise the knowledge and expertise we have developed here in Wales. The proposed research involves a new collaboration between Bangor applicants and the recently established company Broken String Biosciences Ltd., which offers assays that are complementary to the assays we have been developing. In the long term, we believe there is significant potential for impact and commercial exploitation of our assays, e.g. by influencing requirements for genotoxic assessment of nucleoside analogue drugs and offering our expertise and novel assays as a commercial service for pharmaceutical companies to assess the on- and off-target effects of candidate nucleoside analogue drugs.

  Funding awarded through the Bangor University Innovation and Impact Award (Research Wales Innovation Funding). Value = £45,942

  1 Ebr 2022 – 31 Maw 2023

  Gweithgaredd: Arall (Cyfrannwr)

• Phase biolabs subcontract

  01/04/2023 – 31/01/2025 (Wrthi'n gweithredu)