Dr Christopher Staples
Uwch Ddarlithydd mewn Gwyddorau Biofeddygol (Bioleg Canser)
Cymwysterau
- PhD: Regulation of MAP kinase phosphatases
University of Dundee, 2006–2010
Addysgu ac Arolygiaeth
Teaching Credits
MSE-3016 Pathophysiology (10 credits) - Module Organiser
MSE-2025 Molecular Biology and Biochemistry (10 credits)
MSE-3013 Third Year Research Project
MSE-4025 Dissertation
Teaching and Supervision Roles
Undergraduate project/dissertation supervision. Supervision of PhD, MSc and MRes students.
Other roles
College representative on Research Concordat Committee
External and internal viva voce examiner
Teaching and Scholarship Awards
PGCertHE Stage 1 (2017)
PGCertHE Stage 2 (2018)
Fellow of the Higher Education Academy (HEA)
Diddordebau Ymchwil
Work in the Staples laboratory focuses largely on the characterisation of novel genome stability factors. Genome instability and DNA damage are central pathogenic mechanisms involved in cancer predisposition, premature ageing and neurodegeneration. Indeed, some cancer therapies target cancer-specific defects in DNA repair or replication fork protection mechanisms, and as such a complete understanding of such mechanisms is a major asset in the fight against cancer.
We have identified several novel DNA repair and replication fork protection factors, and our aim is to gain mechanistic insight into the function of these largely unstudied proteins with the ultimate goal of using this knowledge to design novel cancer therapies and/or predict therapeutic response.
Cyfleoedd Project Ôl-radd
Cyhoeddiadau
2023
- CyhoeddwydCDK4/6 inhibitor-mediated cell overgrowth triggers osmotic and replication stress to promote senescence
Crozier, L., Foy, R., adib, R., Kar, A., Holt, J., Pareri, A., Valverde, J., Riviera, R., Weston, W., Wilson, R., Regnault, C., Whitfield, P., Badonyi, M., Bennett, L., Vernon, E., Gamble, A., Marsh, J., Staples, C., Saurin, A., Barr, A. & Ly, T., 16 Tach 2023, Yn: Molecular Cell. 83, 22, t. 4062-4077 15 t.
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid - CyhoeddwydRuthenium(II) Polypyridyl Complexes as FRET Donors: Structure- and Sequence-Selective DNA-Binding and Anticancer Properties
Elgar, C. E., Yusoh, N. A., Tiley, P. R., Kolozsvári, N., Bennett, L., Gamble, A., Péan, E. V., Davies, M. L., Staples, C., Ahmad, H. & Gill, M. R., 18 Ion 2023, Yn: Journal of the American Chemical Society. 145, 2, t. 1236-1246 11 t.
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
2020
- CyhoeddwydMRNIP is a replication fork protection factor
Bennett, L., Wilkie, A., Antonopoulou, E., Ceppi, I., Sanchez, A., Vernon, E., Gamble, A., Myers, K. N., Collis, S. J., Cejka, P. & Staples, C., 10 Gorff 2020, Yn: Science Advances. 6, 28, 10 t., eaba5974.
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
2017
- CyhoeddwydApproaches for Identifying Novel Targets in Precision Medicine: Lessons from DNA Repair
Williams, D. T. & Staples, C., 25 Awst 2017, Personalised Medicine. El-Khamisy, S. (gol.). Springer, Cyfrol 1007. t. 1-16 16 t. (Advances in Experimental Medicine and Biology).
Allbwn ymchwil: Pennod mewn Llyfr/Adroddiad/Trafodion Cynhadledd › Pennod
2016
- CyhoeddwydHuman CDK18 promotes replication stress signaling and genome stability
Barone, G., Staples, C. J., Ganesh, A., Patterson, K. W., Bryne, D. P., Myers, K. N., Patil, A. A., Eyers, C. E., Maslen, S., Skehel, J. M., Eyers, P. A. & Collis, S. J., 14 Hyd 2016, Yn: Nucleic Acids Research. 44, 18, t. 8772-8785 14 t.
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid - CyhoeddwydMRNIP/C5orf45 Interacts with the MRN Complex and Contributes to the DNA Damage Response
Staples, C. J., Barone, G., Myers, K. N., Ganesh, A., Gibbs-Seymour, I., Patil, A. A., Beveridge, R. D., Daye, C., Beniston, R., Maslen, S., Ahel, I., Skehel, J. M. & Collis, S. J., 6 Medi 2016, Yn: Cell. 16, 10, t. 2565-75 11 t.
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid - CyhoeddwydThe bornavirus-derived human protein EBLN1 promotes efficient cell cycle transit, microtubule organisation and genome stability
Myers, K. N., Barone, G., Ganesh, A., Staples, C. J., Howard, A. E., Beveridge, R. D., Maslen, S., Skehel, J. M. & Collis, S. J., 14 Hyd 2016, Yn: Scientific Reports. 6, t. 35548
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
2014
- CyhoeddwydCcdc13 is a novel human centriolar satellite protein required for ciliogenesis and genome stability
Staples, C. J., Myers, K. N., Beveridge, R. D., Patil, A. A., Howard, A. E., Barone, G., Lee, A. J., Swanton, C., Howell, M., Maslen, S., Skehel, J. M., Boutlon, S. J. & Collis, S. J., 1 Gorff 2014, Yn: Journal of Cell Science. 127, t. 2910-2919
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid - CyhoeddwydThe leukemia-associated Rho guanine nucleotide exchange factor LARG is required for efficient replication stress signaling
Beveridge, R. D., Staples, C. J., Patil, A. A., Myers, K. N., Maslen, S., Skehel, J. M., Boulton, S. J. & Collis, S. J., 29 Hyd 2014, Yn: Cell Cycle. 13, 21, t. 3450-3459
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
2011
- CyhoeddwydPhosphorylation of the kinase interaction motif in mitogen-activated protein (MAP) kinase phosphatase-4 mediates cross-talk between protein kinase A and MAP kinase signaling pathways
Dickinson, R. J., Delavaine, L., Cejudo-Marín, R., Stewart, G., Staples, C. J., Didmon, M. P., Trinidad, A. G., Alonso, A., Pulido, R. & Keyse, S. M., 4 Tach 2011, Yn: Journal of Biological Chemistry. 286, 44, t. 38018-26 9 t.
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
2010
- CyhoeddwydCross-talk between the p38alpha and JNK MAPK pathways mediated by MAP kinase phosphatase-1 determines cellular sensitivity to UV radiation
Staples, C. J., Owens, D. M., Maier, J. V., Cato, A. C. B. & Keyse, S. M., 20 Awst 2010, Yn: Journal of Biological Chemistry. 285, 34, t. 25928-40 13 t.
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
2009
- CyhoeddwydRegulation of the inducible nuclear dual-specificity phosphatase DUSP5 by ERK MAPK
Kucharska, A., Rushworth, L. K., Staples, C., Morrice, N. A. & Keyse, S. M., Rhag 2009, Yn: Cellular Signalling. 21, 12, t. 1794-805 12 t.
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
2008
- CyhoeddwydNegative-feedback regulation of FGF signalling by DUSP6/MKP-3 is driven by ERK1/2 and mediated by Ets factor binding to a conserved site within the DUSP6/MKP-3 gene promoter
Ekerot, M., Stavridis, M. P., Delavaine, L., Mitchell, M. P., Staples, C., Owens, D. M., Keenan, I. D., Dickinson, R. J., Storey, K. G. & Keyse, S. M., 1 Meh 2008, Yn: Biochemical Journal. 412, 2, t. 287-98 12 t.
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
2007
- CyhoeddwydBiophysical properties of salmonid alphaviruses: influence of temperature and pH on virus survival
Graham, D. A., Staples, C., Wilson, C. J., Jewhurst, H., Cherry, K., Gordon, A. & Rowley, H. M., Medi 2007, Yn: Journal of Fish Biology. 30, 9, t. 533-43 11 t.
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
Gweithgareddau
2022
- BU-IIA Funded Project: Drug Target in Pancreatic Cancer
There is an urgent requirement to identify specific, precision medicine drug targets that selectively kill PDACs with mutations in BRCA2 and other DNA repair factors, or which sensitise them further to existing treatments. We are therefore applying for funding to develop CRISPR-Cas9 dropout screening at Bangor –a powerful technique for identifying novel precision medicine drug targets in cancer cells. While our initial focus is on PDAC, once in place this methodology can be applied to drive the discovery of drug targets for a wide array of human diseases.
Funding awarded through the Bangor University Innovation and Impact Award (Research Wales Innovation Funding). Value = £49,466
1 Ebr 2022 – 31 Maw 2023
Gweithgaredd: Arall (Cyfrannwr)
2021
- BBSRC reviewer
20 Meh 2021
Gweithgaredd: Mathau o waith ymgysylltu academaidd allanol - Cyfraniad at waith pwyllgorau a gweithgorau cenedlaethol neu ryngwladol (Cyfrannwr) - The Role of HERC2 in Ciliogenesis
Invited talk at the 26th UK Cilia Network Symposium
17 Mai 2021
Gweithgaredd: Cyflwyniad llafar (Siaradwr) - NWCR Scientific Committee Membership
Member of scientific panel
9 Mai 2021 →
Gweithgaredd: Mathau o waith ymgysylltu academaidd allanol - Cyfraniad at waith pwyllgorau a gweithgorau cenedlaethol neu ryngwladol (Cyfrannwr) - Peer reviewer for the Humane Research Trust
9 Mai 2021
Gweithgaredd: Mathau o waith ymgysylltu academaidd allanol - Cyfraniad at waith pwyllgorau a gweithgorau cenedlaethol neu ryngwladol (Cyfrannwr)
2020
- DNA Repair (Cyfnodolyn)
Peer reviewer
7 Tach 2020
Gweithgaredd: Adolygu cyhoeddiadau cymheiriaid (Aelod o fwrdd golygyddol) - Peer-reviewer for UKRI Future Leaders Fellowships
Peer-reviewer for UKRI Future Leaders Fellowships
25 Hyd 2020
Gweithgaredd: Mathau o waith ymgysylltu academaidd allanol - Cyfraniad at waith pwyllgorau a gweithgorau cenedlaethol neu ryngwladol (Cyfrannwr) - Molecular Oncology (Cyfnodolyn)
Peer review
11 Medi 2020
Gweithgaredd: Adolygu cyhoeddiadau cymheiriaid (Aelod o fwrdd golygyddol) - BBSRC Peer Review
Reviewed a BBSRC Responsive Mode Application
31 Awst 2020
Gweithgaredd: Mathau o waith ymgysylltu academaidd allanol - Cyfraniad at waith pwyllgorau a gweithgorau cenedlaethol neu ryngwladol (Cyfrannwr) - Internal Examiner for PhD Viva
21 Ebr 2020
Gweithgaredd: Arholiad (Arholwr) - Chair for PhD Viva
2 Ebr 2020
Gweithgaredd: Arholiad (Arholwr) - Peer review
Provided peer review for a BBSRC project grant application
4 Maw 2020
Gweithgaredd: Mathau o waith ymgysylltu academaidd allanol - Cyfraniad at waith pwyllgorau a gweithgorau cenedlaethol neu ryngwladol (Cyfrannwr) - PLoS Biology (Cyfnodolyn)
Acted as peer reviewer
7 Ion 2020
Gweithgaredd: Adolygu cyhoeddiadau cymheiriaid (Aelod o fwrdd golygyddol)
2019
- External examiner for PhD candidate in Lancaster
Supervised by Nikki Copeland
13 Meh 2019
Gweithgaredd: Arholiad (Arholwr) - Examined Prof Ciaran Morrisons PhD student (Galway)
External examiner
4 Meh 2019
Gweithgaredd: Arholiad (Arholwr) - MRNIP is a novel replication fork protection factor
15 min talk at international conference
2019
Gweithgaredd: Cyflwyniad llafar (Siaradwr)
2018
- Novel players in replication fork protection
Invited speaker to research seminar series
18 Maw 2018
Gweithgaredd: Cyflwyniad llafar (Siaradwr) - External examiner for MRes viva
29 Ion 2018
Gweithgaredd: Arholiad (Arholwr)
2017
- Internal Examiner for PhD viva
9 Tach 2017
Gweithgaredd: Arholiad (Arholwr) - The role of MRNIP in DNA repair
Invited speaker to research seminar series
11 Mai 2017
Gweithgaredd: Cyflwyniad llafar (Siaradwr)
Projectau
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New radiosensitizers for triple-negative breast cancer
01/07/2024 – 15/07/2027 (Wrthi'n gweithredu)
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Daughter Strand Gaps as determinants of chemoresistance
03/06/2024 – 30/06/2026 (Wrthi'n gweithredu)
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A novel role for the innate immune sensor IFI16 in the cancer cell response to chemotherapy
01/01/2024 – 15/01/2026 (Wrthi'n gweithredu)
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Regulation of chemosensitivity by the novel daughter strand gap suppressor MRNIP
01/12/2023 – 15/12/2026 (Wrthi'n gweithredu)
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01/10/2023 – 30/11/2026 (Wrthi'n gweithredu)
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Wales Cancer Research Centre / Overcoming breast cancer resistance to CDK4/6 inhibitors.'
01/04/2023 – 15/04/2025 (Wrthi'n gweithredu)
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Daughter strand gaps as crucial determinants of therapeutic response
01/10/2022 – 31/12/2025 (Wrthi'n gweithredu)
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KESS II MRes with NWCR - BUK2E089
01/10/2022 – 31/03/2024 (Wedi gorffen)
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KESS II MRes with BEE Robotics BUK2E081
01/07/2022 – 31/03/2024 (Wedi gorffen)
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HEFCW HEIR COVID extension to UKRI FLF MRC bid (F008177, R49R01, MR/S034579/1)
01/05/2021 – 31/08/2021 (Wedi gorffen)
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KESS II MRes with North West Cancer Research BUK2225
01/01/2021 – 31/03/2024 (Wedi gorffen)
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KKESS II East Phd with North West Cancer Research BUK2E019
01/02/2020 – 29/02/2024 (Wedi gorffen)
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The role of MRNIP in replication fork stabilisation and DSB repair
01/12/2019 – 31/12/2023 (Wedi gorffen)
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Potential roles of MRNIP and IFI16 in linking oncogene-induced replication
01/07/2019 – 01/08/2022 (Wedi gorffen)
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Replication fork reversal and stability (UNS87415 Mr Anuj Narwal)
01/06/2019 – 01/08/2019 (Wedi gorffen)
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Investigation of novel regulators of genome stability
01/01/2019 – 30/06/2022 (Wedi gorffen)
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Autophagy dependent survival following Mec1(ATM/ATR) inactivation
01/05/2018 – 31/07/2023 (Wedi gorffen)
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Role of RadIP, a novel DNA repair factor in the DNA damage response to chemotherapy.
01/11/2016 – 31/08/2020 (Wedi gorffen)
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Targeting CtIP to sensitise cancer cells to DNA-damaging agents
01/10/2016 – 31/07/2018 (Wedi gorffen)
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Therapeutically relevant novel links between DNA damage and ciliogenesis
01/10/2016 – 19/08/2023 (Wedi gorffen)