Dr Pierce has an extensive research background in haemopoietic stem cell biology with a special interest in the myeloid leukaemias. Having undertaken a systematic analysis of leukaemogenic protein tyrosine kinases using systems biology approaches and advanced mass spectrometry techniques (iTRAQ, SILAC, SWATH, proteogenomics and phosphopeptide analysis) he identified common effectors driving multiple leukaemias. Targeting these disrupted pathways in primary patient material and in in vivo model systems he was able to demonstrate their potential as novel treatment strategies. Much of this work included repurposing drugs with the explicit aim of improving leukaemia patient outcomes. Repurposing drugs bypasses many of the hurdles present in drug development, such as toxicity and pharmacodynamic profiling markedly reducing the time and cost to advance new treatments to the clinic. His work has also shown that mRNA level changes do not correspond to protein level changes in response to oncogene expression and that modulation of the mRNA export complex, THOC, can in part explain this phenomenon. This work is presently being expanded into research on alternative splicing in cancer, both via mutation of proteins involved in RNA splicing and as a response to radiotherapy in the context of DNA damage. Using his expertise in proteomics and ability to lead multidisciplinary teams Dr Pierce has also driven research projects in cancer biomarker discovery. All of Dr Pierce’s research is ultimately aimed at improving patient outcomes.

Location: Brambell, Room 412

Email: a.pierce@bangor.ac.uk

Current Position: Lecturer, Medical and Health Sciences

Other external Positions: Honorary Lecturer, Division of Cancer Sciences, The University of Manchester

Teaching

Programme lead for Genomics and Precision Medicine MSc.

Module coordinator for MSE-4080, Bioinformatics and Genomic data.

Module coordinator for MSE-4081, Omics Techniques and Technologies.

Module coordinator for MSE-4083, Genomics and Cancer.

Supervision

Supervision of PhD, MSc and MRes students.

Other roles

External and internal viva voce examiner

Research Impact

Developing cancer therapies that eradicate cancer stem cells and cure the disease is hugely challenging which is exemplified in Chronic Myeloid Leukaemia, an advanced paradigm of cancer stem cell research. Dr Pierce has published a true ‘’bench to bedside’’ study (Nature, 2016. PMID: 27281222) where a proteomic screen of primary leukaemic progenitor cells led to the identification of a potential cure for chronic myeloid leukaemia which entered a phase 2 clinical trial (CRUK/17/016 TASTER). Similar approaches have led to the identification of potential treatments for Polycythemia vera (Leukemia, 2017. PMID: 28533538), Juvenile Myelomonocytic leukemia (JPR, 2020. PMID: 31657576), and Chronic Myeloid leukemia (PlosOne, 2022. PMID: 35358275). A further study (Hemasphere 2019. PMID: 31723838) reporting the potential of repurposing the drug BGB324 for the treatment of myeloproliferative neoplasms prompted the company developing the drug, in clinical trial for several solid tumours, to investigate its potential in in vivo models of myeloproliferative neoplasm (Hemasphere, 2021. PMID: 34396051). This study concluded that BGB324 warrants clinical investigation for the treatment of MPN.

Endometrial cancer is the most common gynaecological malignancy in high-income countries and the sixth most common cancer in women worldwide. Early detection is key to ensuring good clinical outcomes and a non-invasive detection tool would transform patient care.  Dr Pierce has published research (Cancers, 2021. PMID: 34359700 PMID: 33578729) which has identified potential biomarkers in urine and plasma that are undergoing validation as a patient friendly endometrial cancer detection test.

’Rydwyf yn fodlon goruchwylio cwrs PhD

2024

• CyhoeddwydDetection of endometrial cancer in cervico-vaginal fluid and blood plasma: Leveraging proteomics and machine learning for biomarker discover
  Njoku, K., Pierce, A., Chiasserini, D., Geary, B., Campbell, A. E., Kelsall, J., Reed, R., Geifman, N., Whetton, A. D. & Crosbie, E. J., Ebr 2024, Yn: eBioMedicine. 102, t. 105064
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2023

• CyhoeddwydIdentification of curaxin as a potential new therapeutic for JAK2 V617F mutant patients
  Pearson, S., Blance, R., Yan, F., Hsieh, Y.-C., Geary, B., Amaral, F. M. R., Somervaille, T. C. P., Kirschner, K., Whetton, A. D. & Pierce, A., 30 Mai 2023, Yn: PLoS ONE. 18, 5, 16 t., 0286412.
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
• CyhoeddwydQuantitative SWATH-based proteomic profiling of urine for the identification of endometrial cancer biomarkers in symptomatic women
  Njoku, K., Pierce, A., Geary, B., Campbell, A. E., Kelsall, J., Reed, R., Armit, A., Da Sylva, R., Zhang, L., Agnew, H., Baricevic-Jones, I., Chiasserini, D., Whetton, A. D. & Crosbie, E. J., 18 Mai 2023, Yn: British Journal of Cancer. 128, 9, t. 1723-1732 10 t.
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
• CyhoeddwydTHOC5 complexes with DDX5, DDX17, and CDK12 to regulate R loop structures and transcription elongation rate
  Polenkowski, M., Allister, A. B., Burbano de Lara, S., Pierce, A., Geary, B., El Bounkari, O., Wiehlmann, L., Hoffmann, A., Whetton, A. D., Tamura, T. & Tran, D. D. H., 20 Ion 2023, Yn: iScience. 26, 1, 105784.
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2022

• CyhoeddwydCombination of curaxin and tyrosine kinase inhibitors display enhanced killing of primitive Chronic Myeloid Leukaemia cells
  Pearson, S., D. Whitton, A. & Pierce, A., 31 Maw 2022, Yn: PLoS ONE. 17, 3, 11 t., e0266298.
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
• CyhoeddwydHMG20B stabilizes association of LSD1 with GFI1 on chromatin to confer transcription repression and leukemia cell differentiation block
  Maiques-Diaz, A., Nicosia, L., Basma, N. J., Romero-Camarero, I., Camera, F., Spencer, G. J., Amaral, F. M. R., Simeoni, F., Wingelhofer, B., Williamson, A. J. K., Pierce, A., Whetton, A. D. & Somervaille, T. C. P., 28 Hyd 2022, Yn: Oncogene. 41, 44, t. 4841-4854 14 t.
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2021

• CyhoeddwydComprehensive library generation for identification and quantification of endometrial cancer protein biomarkers in cervico-vaginal fluid
  Njoku, K., Chiasserini, D., Geary, B., Pierce, A., Jones, E. R., Whetton, A. & Crosbie, E., 23 Gorff 2021, Yn: Cancers.
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
• CyhoeddwydMetabolomic Biomarkers for the Detection of Obesity-Driven Endometrial Cancer
  Njoku, K., Campbell, A. E., Geary, B., MacKintosh, M. L., Derbyshire, A. E., Kitson, S. J., Sivalingam, V. N., Pierce, A., Whetton, A. D. & Crosbie, E. J., 10 Chwef 2021, Yn: Cancers. 13, 4, t. 718 1 t.
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2020

• CyhoeddwydEVI1 oncoprotein expression and CtBP1-association oscillate through the cell cycle
  Paredes, R., Schneider, M., Pearson, S., Teng, H. Y., Kelly, J. R., Pierce, A., Somervaille, T. C. P., Whetton, A. D. & Meyer, S., 2020, Yn: Molecular Biology Reports. 47, 10, t. 8293-8300 8 t.
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
• CyhoeddwydEVI1-phosphorylation at S436 regulates interactions with CtBP1 and DNMT3A and promotes self-renewal
  Paredes, R., Kelly, J., Geary, B., Almarzouq, B., Schneider, M., Pearson, S., Narayanan, P., Williamson, A., Lovell, S., Wiseman, D., Chadwick, J., Jones, N. J., Kustikova, O., Schambach, A., Garner, T., Amaral, F., Pierce, A., Stevens, A., Somervaille, T., Whetton, A. & Meyer, S., 20 Hyd 2020, Yn: Cell Death and Disease. 11
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
• CyhoeddwydIntegrated nuclear proteomics and transcriptomics identifies S100A4 as a therapeutic target in acute myeloid leukemia
  Alanazi, B., Munje, C. R., Rastogi, N., Williamson, A. J. K., Taylor, S., Hole, P. S., Hodges, M., Doyle, M., Baker, S., Gilkes, A. F., Knapper, S., Pierce, A., Whetton, A. D., Darley, R. L. & Tonks, A., 2020, Yn: Leukemia. 34, 2, t. 427-440 14 t.
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2019

• CyhoeddwydAXL inhibition extinguishes primitive JAK2 mutated myeloproliferative neoplasm progenitor cells
  Pearson, S., Blance, R., Somervaille, T., Whetton, A. & Pierce, A., 24 Ebr 2019, Yn: HemaSphere.
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
• CyhoeddwydOncogenic MYC amplifies mitotic perturbations
  Taylor, S., Littler, S., Sloss, O., Geary, B., Pierce, A. & Whetton, A., 28 Awst 2019, Yn: Open Biology.
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
• CyhoeddwydProteomic analysis of an induced pluripotent stem cell model reveals strategies to treat Juvenile Myelomonocytic Leukaemia
  Pearson, S., Guo, B., Pierce, A., Azadbakht, N., Brazzatti, J. A., Patassini, S., Mulero-navarro, S., Meyer, S., Flotho, C., Gelb, B. D. & Whetton, A. D., 2019, Yn: Journal of Proteome Research.
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2018

• CyhoeddwydEVI1 carboxy-terminal phosphorylation is ATM-mediated and sustains transcriptional modulation and self-renewal via enhanced CtBP1 association
  Paredes, R., Schneider, M., Stevens, A., White, D. J., Williamson, A. J. K., Muter, J., Pearson, S., Kelly, J. R., Connors, K., Wiseman, D. H., Chadwick, J. A., Löffler, H., Teng, H. Y., Lovell, S., Unwin, R., van de Vrugt, H. J., Smith, H., Kustikova, O., Schambach, A., Somervaille, T. C. P., Pierce, A., Whetton, A. D. & Meyer, S., 1 Meh 2018, Yn: Nucleic Acids Research. 46, 15, t. 7662-7674 13 t.
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2017

• CyhoeddwydAcquired cross-linker resistance associated with a novel spliced BRCA2 protein variant for molecular phenotyping of BRCA2 disruption
  Meyer, S., Stevens, A., Paredes, R., Schneider, M., Walker, M. J., Williamson, A. J. K., Gonzalez-Sanchez, M.-B., Smetsers, S., Dalal, V., Teng, H. Y., White, D. J., Taylor, S., Muter, J., Pierce, A., de Leonibus, C., Rockx, D. A. P., Rooimans, M. A., Spooncer, E., Stauffer, S., Biswas, K., Godthelp, B., Dorsman, J., Clayton, P. E., Sharan, S. K. & Whetton, A. D., 2017, Yn: Cell Death and Disease. 8, 6, t. e2875-e2875
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
• CyhoeddwydProteomic analysis of JAK2V617F-induced changes identifies potential new combinatorial therapeutic approaches.
  S, P., AJK, W., R, B., TCP, S., S, T., N, A., AD, W. & A, P., 1 Rhag 2017, Yn: Leukemia. 31
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2016

• CyhoeddwydDevelopment of a selected reaction monitoring mass spectrometry-based assay to detect asparaginyl endopeptidase activity in biological fluids.
  A, D., DN, P., MJ, W., OJ, G., C, P., M, H., AJ, W., Pierce, A., A, P., RD, U., S, K., V, S. & AD, W., 2016, Yn: Oncotarget.
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
• CyhoeddwydDual targeting of p53 and c-MYC selectively eliminates leukaemic stem cells.
  SA, A., LE, H., E, C., ME, D., K, D., AJ, W., K, K., P, B., LE, P., MT, S., F, P., Pierce, A., M, C., C, N., SM, G., D, V., AD, W. & TL, H., 2016, Yn: Nature. 534, t. 341-346
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
• CyhoeddwydERK and AKT phosphorylation status in lung cancer and emphysema using nanocapillary isoelectric focusing.
  PA, C., EJ, C., M, A.-O., M, W., R, H., M, P., R, S., L, J., R, B., A, P. & AD, W., 2016, Yn: BMJ Open Respiratory Research.
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
• CyhoeddwydMPL W515L expression induces TGFβ secretion and leads to an increase in chemokinesis via phosphorylation of THOC5
  AD, W., NC, A., S, P., E, J., L, Z., R, B., AC, K., A, N., S, T., AJ, W. & A, P., 2016, Yn: Oncotarget.
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2015

• CyhoeddwydAntibody-based detection of protein phosphorylation status to track the efficacy of novel therapies using nanogram protein quantities from stem cells and cell lines.
  M, A.-O., Pierce, A., F, P., AJ, W., MT, S., MJ, W., TL, H. & AD, W., 2015, Yn: Natur Protocols.
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2014

• CyhoeddwydA hierarchical statistical modeling approach to analyze proteomic isobaric tag for relative and absolute quantitation data.
  C, Z., MJ, W., AJ, W., A, P., C, B., C, D. & AD, W., 15 Rhag 2014, Yn: Bioinformatics. t. 549-558
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
• CyhoeddwydTHOC5 controls 3'end-processing of immediate early genes via interaction with polyadenylation specific factor 100 (CPSF100).
  DD, T., S, S., AJ, W., Pierce, A., O, D.-B., L, W., A, K., AD, W. & T, T., 2014, Yn: Nucleic Acids Research. 42, 19
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
• CyhoeddwydThe antiproliferative activity of kinase inhibitors in chronic myeloid leukemia cells is mediated by FOXO transcription factors.
  F, P., MT, S., GV, H., LE, H., EK, A., M, A.-O., M, C., A, P., BJ, H., AD, W. & TL, H., 18 Awst 2014, Yn: Stem Cells. 32, 9, t. 2324-2337
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2013

• CyhoeddwydA pathway from leukemogenic oncogenes and stem cell chemokines to RNA processing via THOC5.
  F, G., A, P., MB, G. S., M, S., SA, A., TL, H., DD, T., T, T. & AD, W., 3 Hyd 2013, Yn: Leukemia. 27, t. 932-940
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
• CyhoeddwydA specific PTPRC/CD45 phosphorylation event governed by stem cell chemokine CXCL12 regulates primitive hematopoietic cell motility.
  AJ, W., A, P., E, J., C, Z., M, A.-O., L, L., RD, U., SA, A., MJ, W., S, C., E, S., TL, H. & AD, W., 1 Tach 2013, Yn: Molecular and Cellular Proteomics. 3319 t.
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
• CyhoeddwydPhosphorylation of the leukemic oncoprotein EVI1 on serine 196 modulates DNA binding, transcriptional repression and transforming ability.
  DJ, W., RD, U., E, B., A, P., HY, T., J, M., B, G., TD, S., J, G., S, L., TC, S., R, D., AD, W. & S, M., 12 Meh 2013, Yn: PLoS ONE.
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
• CyhoeddwydTransglutaminase 2 expression in acute myeloid leukemia: association with adhesion molecule expression and leukemic blast motility.
  Pierce, A., AD, W., S, M., F, R.-K., G, B., KR, C., N, Z. & S, K., 11 Ebr 2013, Yn: Proteomics. 13, 14, t. 2216-2224
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2012

• CyhoeddwydBCR/ABL modulates protein phosphorylation associated with the etoposide-induced DNA damage response.
  F, G., AJ, W., S, T., DN, P., E, S., A, P. & AD, W., 12 Meh 2012, Yn: Journal of Proteomics. 77, t. 14-26
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
• CyhoeddwydCorrection: Identification of nuclear protein targets for six leukemogenic tyrosine kinases governed by post-translational regulation (PLoS ONE)
  Pierce, A., Williamson, A., Jaworska, E., Griffiths, J. R., Taylor, S., Walker, M., Aspinall O'Dea, M., Spooncer, E., Unwin, R. D., Poolman, T., Ray, D. & Whetton, A. D., 2012, Yn: PLoS ONE. 8, 6
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2010

• CyhoeddwydAssessment of downstream effectors of BCR/ABL protein tyrosine kinase using combined proteomic approaches.
  CF, L., S, G., E, R.-S., A, P., RD, U., E, J., CA, E., S, J. G. & AD, W., 2 Medi 2010, Yn: Proteomics. 10, 18, t. 3321-3342
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
• CyhoeddwydProteomic analysis reveals a novel mechanism induced by the leukemic oncogene Tel/PDGFR activation of the interferon response pathways.
  E, D., C, G., RW, F., RD, U., JR, G., A, P., AD, W. & H, W., Tach 2010, Yn: Stem Cell Research. 5, 3, t. 226-243
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2009

• CyhoeddwydTHOC5 couples M-CSF receptor signaling to transcription factor expression.
  L, C., A, P., M, R., MB, G. S., HG, H., L, Z., T, T. & AD, W., Chwef 2009, Yn: Cellular Signalling. 21, 2, t. 309-316
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2008

• CyhoeddwydEight-channel iTRAQ enables comparison of the activity of six leukemogenic tyrosine kinases.
  Pierce, A., RD, U., CA, E., S, G., L, C., L, Z., E, J., CF, L., D, B., MJ, O., CJ, M., DA, B., E, S. & AD, W., 1 Mai 2008, Yn: Molecular and Cellular Proteomics. 7, 5, t. 853-863
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
• CyhoeddwydTHOC5 spliceosome protein: a target for leukaemogenic tyrosine kinases that affects inositol lipid turnover.
  Pierce, A., L, C., HG, H., JR, G., L, Z., BA, W., MB, G. S., T, T., D, S. & AD, W., 15 Ebr 2008, Yn: British Journal of Haematology. 141, 5, t. 641-650
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2006

• CyhoeddwydA novel mechanism for BCR-ABL action: stimulated secretion of CCN3 is involved in growth and differentiation regulation.
  L, M., S, P., N, P., B, P., A, P., AD, W. & AE, I., 2006, Yn: Blood. t. 1716-1723
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
• CyhoeddwydDifferential effect of leukaemogenic tyrosine kinases on cell motility is governed by subcellular localisation.
  Pierce, A., Y, L., HG, H., S, T., PJ, O.-L., AD, W. & E, S., 31 Maw 2006, Yn: British Journal of Haematology. 133, 3, t. 345-352
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
• CyhoeddwydQuantitative proteomics reveals posttranslational control as a regulatory factor in primary hematopoietic stem cells.
  RD, U., DL, S., D, B., CL, W., CJ, M., CA, E., E, J., SA, B., K, B., A, P., E, S. & AD, W., 15 Meh 2006, Yn: Blood. 107, 12, t. 4687-4694
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
• CyhoeddwydRole of the C-terminal actin binding domain in BCR/ABL-mediated survival and drug resistance.
  N, U.-D., Pierce, A., SE, T., D, X., AD, W. & PJ, O.-L., 13 Chwef 2006, Yn: British Journal of Haematology. 132, 6, t. 774-783
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2005

• CyhoeddwydChronic myeloid leukemia CD34+ cells have elevated levels of phosphatidylinositol 3,4,5 trisphosphate (PtdIns(3,4,5)P3) and lack a PtdIns(3,4,5)P3 response to cytokines and chemotactic factors; effects reversed by imatinib.
  HG, H., Pierce, A., WA, S., C, P. D., A, G., A, I., E, S. & AD, W., 18 Awst 2005, Yn: Leukemia. t. 1851-1853
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
• CyhoeddwydGlobal effects of BCR/ABL and TEL/PDGFRbeta expression on the proteome and phosphoproteome: identification of the Rho pathway as a target of BCR/ABL.
  RD, U., DW, S., Y, L., A, P., DG, G. & AD, W., Chwef 2005, Yn: Journal of Biological Chemistry. 280, 8, t. 6316-6326
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
• CyhoeddwydQuantitative proteomic analysis using isobaric protein tags enables rapid comparison of changes in transcript and protein levels in transformed cells.
  Pierce, A., RD, U., A, P., RB, W., DW, S. & AD, W., 1 Gorff 2005, Yn: Molecular and Cellular Proteomics. 4, 7
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2004

• CyhoeddwydBcr-Abl-mediated molecular mechanism for apoptotic suppression in multipotent haemopoietic cells: a role for PKCbetaII.
  D, X., Pierce, A., N, U.-D., AD, W. & PJ, O.-L., Chwef 2004, Yn: Cellular Signalling. 16, 2, t. 145-156
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
• CyhoeddwydComparative proteomics of primitive hematopoietic cell populations reveals differences in expression of proteins regulating motility.
  CA, E., R, T., D, B., A, P., J, S., Y, L., HG, H., A, G., CP, D., SJ, G., E, S. & AD, W., 15 Mai 2004, Yn: Blood. t. 3751-3759
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2003

• CyhoeddwydGeneration of a conditionally immortalized myeloid progenitor cell line requiring the presence of both interleukin-3 and stem cell factor to survive and proliferate.
  C, L., CA, E., E, S., A, P., R, M. & AD, W., 3 Medi 2003, Yn: British Journal of Haematology. 122, 6, t. 985-995
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
• CyhoeddwydLysophospholipids synergistically promote primitive hematopoietic cell chemotaxis via a mechanism involving Vav 1.
  AD, W., Y, L., A, P., L, C. & E, S., 15 Hyd 2003, Yn: Blood. 102, 8, t. 2798-2802
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2002

• CyhoeddwydBCR-ABL alters the proliferation and differentiation response of multipotent hematopoietic cells to stem cell factor.
  Pierce, A., E, S., S, A. & AD, W., 2002, Yn: Oncogene. 21, t. 3068-3075
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
• CyhoeddwydChanges in the proteome associated with the action of Bcr-Abl tyrosine kinase are not related to transcriptional regulation.
  DL, S., CA, E., A, P., SJ, G. & AD, W., 1 Tach 2002, Yn: Molecular and Cellular Proteomics. 1, 11, t. 876-884
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
• CyhoeddwydIdentification of primary structural features that define the differential actions of IL-3 and GM-CSF receptors.
  CA, E., S, A., A, P. & AD, W., 1 Tach 2002, Yn: Blood. 100, 9, t. 3164-3174
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2001

• CyhoeddwydThe specific enhancement of interferon alpha induced growth inhibition by BCR/ABL only occurs in multipotent cells.
  Pierce, A., DL, S., LV, J., AD, W. & E, S., 2001, Yn: The Hematology Journal. 2, 4, t. 257-264
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2000

• CyhoeddwydBcr-Abl protein tyrosine kinase activity induces a loss of p53 protein that mediates a delay in myeloid differentiation.
  Pierce, A., E, S., S, W., C, D., JM, F., J, M., PJ, O.-L., TM, D. & AD, W., 16 Tach 2000, Yn: Oncogene. 19, t. 5487-5497
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
• CyhoeddwydThe effect of Bcr-Abl protein tyrosine kinase on maturation and proliferation of primitive haematopoietic cells
  AM, B., R, M., A, P., GS, L., N, R., JA, M. & AD, W., 1 Hyd 2000, Yn: Molecular Medicine. 6, t. 892-902
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
• CyhoeddwydTransforming growth factor-beta 1 induces apoptosis independently of p53 and selectively reduces expression of Bcl-2 in multipotent hematopoietic cells.
  JM, F., CM, H., E, S., A, P., TM, D. & AD, W., Rhag 2000, Yn: Journal of Biological Chemistry. 275, 50, t. 39137-39145
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

1999

• CyhoeddwydActivation of granulocyte-macrophage colony-stimulating factor and interleukin-3 receptor subunits in a multipotential hematopoietic progenitor cell line leads to differential effects on development.
  CA, E., Pierce, A., SA, W., E, S., CM, H. & AD, W., 1 Medi 1999, Yn: Blood. 94, 5, t. 1504-1514
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
• Cyhoeddwyd[Influence of chemotherapeutants and cytokines on growth and transgene expression of bone marrow cells from MT/p210(bcr-abl) transgenic mice]
  H, C., Pierce, A. & T, W., Rhag 1999, Yn: Chinese Journal of Cancer Research. 11, t. 245-248
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

1998

• CyhoeddwydAn activated protein kinase C alpha gives a differentiation signal for hematopoietic progenitor cells and mimicks macrophage colony-stimulating factor-stimulated signaling events.
  Pierce, A., CM, H., SE, N., E, S., TM, D., JM, L., PJ, O.-L., G, W. & AD, W., 23 Maw 1998, Yn: Journal of Cell Biology. 140, 6, t. 1511-1518
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
• CyhoeddwydEctopic interleukin-5 receptor expression promotes proliferation without development in a multipotent hematopoietic cell line.
  Pierce, A., AD, W., PJ, O.-L., J, T., E, S., TM, D. & CM, H., 15 Maw 1998, Yn: Journal of Cell Science. t. 815-823
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
• Cyhoeddwydp210 Bcr-Abl expression in a primitive multipotent haematopoietic cell line models the development of chronic myeloid leukaemia.
  Pierce, A., PJ, O.-L., E, S., TM, D. & AD, W., 10 Awst 1998, Yn: Oncogene. 17, t. 667-672
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

1997

• CyhoeddwydHaemopoietic growth factors and leukaemogenesis.
  Pierce, A. & AD, W., 1 Mai 1997, Yn: Biochemical Society Transactions. 25, 2, t. 366-370
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

1996

• CyhoeddwydCellular and Molecular Aspects of Myeloid Cell Proliferation and Development
  Evans, C. A. & Pierce, A., 1996, Blood Cell Biochemistry: Hematopoietic Cell Growth Factors and Their Receptors. Whetton, A. D. & Gordon, J. (gol.). Boston, MA: Springer US, t. 99-120 22 t.
  Allbwn ymchwil: Pennod mewn Llyfr/Adroddiad/Trafodion Cynhadledd › Pennod › adolygiad gan gymheiriaid

1995

• CyhoeddwydMacrophage inflammatory protein-1 alpha receptors are present on cells enriched for CD34 expression from patients with chronic myeloid leukemia.
  RC, C., GS, L., PJ, O.-L., A, P. & AD, W., 1 Rhag 1995, Yn: Blood. 86, 11, t. 4270-4277
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

1992

• CyhoeddwydMolecular cloning of the major cell surface heparan sulfate proteoglycan from rat liver.
  Pierce, A., M, L., IN, H., GJ, C. & JT, G., 25 Chwef 1992, Yn: Journal of Biological Chemistry. 267, 6, t. 3894-3900
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

• KESS II MRes with NWCR - BUK2E090

  01/10/2022 – 31/03/2024 (Wedi gorffen)

GRANTS AWARDED

2020-2023    Fanconi Hope (92K). Investigations into Proton Beam Therapy in Fanconi Anaemia (CoI).

2019-2022    Bloodwise (£300K). Eradication of the leukaemic clone in myeloproliferative neoplasms (PI).

2019-2021    FRGS, MASTIC (35K). The antileukemic activity and mechanisms of action of Lignosus rhinocerotis (CoI).

2013-2018    Leukaemia Lymphoma Research (£1.8M). Application of advanced protein technologies to identify common treatment targets for myeloid leukaemias (CoI).

2016-2016    ISSF Strategic Awards in Precision Medicine (£15K). Developing a plasma-based biomarker for the early identification and stratification of Alzheimer’s disease (CoI).

2016-2016    BloodWise summer studentship (1.5K). CD45 in myeloproliferative neoplasms (PI).

2015-2017    Manchester Royal Infirmary MD studentship (£268K). Assessment of abnormal signal pathway activation in acute myeloid leukaemia characterised by FLT3/ITD: application to treatment design and monitoring (CoI).

Contributions to the Scientific community

Dr Pierce regularly reviews grant applications for international funding bodies and manuscripts for a wide range of internationally renowned journals such as EMBO, Blood, Molecular Cellular Proteomics and Oncogene. He has also served as external Ph.D. examiner. Dr Pierce has collaborated widely both nationally and internationally having published research manuscripts with groups from amongst others Manchester, Liverpool, Glasgow, Cardiff, Hanover, Frieberg, Houston and New York.

Work Biography

Previous Positions

2005 – 2022            Research Fellow, Stem Cell and Leukaemia Proteomics Laboratories University of Manchester

1998 - 2005             Research Fellow, Cellular Development Unit, UMIST

1992 - 1998             Research Associate, Cellular Development Unit, UMIST

Education

1989 - 1992            PhD: The cloning and sequencing of plasma membrane Heparan Sulphate Proteoglycans. Paterson Institute for Cancer Research, Manchester.