Dr Edgar Hartsuiker
Uwch Ddarlithydd mewn Gwyddorau Biofeddygol (Bioleg Canser)
Cyhoeddiadau
2023
- CyhoeddwydSelective Killing of BRCA2-Deficient Ovarian Cancer Cells via MRE11 Blockade
Alblihy , A., Ali , R., Algethami, M., Ritchie, A. A., Shoqafi, A., Alqahtani, S., Mesquita, K. A., Toss, M. S., Ordóñez-Morán , P., Jeyapalan, J. N., Dekker , L., Salerno, M., Hartsuiker, E., Grabowska , A. M., Rakha, E. A., Mongan, N. P. & Madhusudan, S., 30 Meh 2023, Yn: International journal of molecular sciences. 24, 13
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
2020
- CyhoeddwydData presenting the synthesis of three novel stimuli responsive hyperbranched polymers synthesised via RAFT polymerisation and the bio conjugation of folic acid
Blackburn, C., Tai, H., Salerno, M., Wang, X., Senan, C., Ratcliffe, I., Hartsuiker, E. & Wang, W., Chwef 2020, Yn: Data in Brief. 28, 104861.
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid - CyhoeddwydMre11 exonuclease activity removes the chain-terminating nucleoside analog gemcitabine from the nascent strand during DNA replication
Böckemeier, L., Kraehenbuehl, R., Keszthelyi, A., Gasasira, M. U., Vernon, E., Beardmore, R., Broberg Vågbø, C., Chaplin, D., Collins, S., Krokan, H. E., Lambert, S. A. E., Paisz, B. & Hartsuiker, E., 29 Mai 2020, Yn: Science Advances. 6, 22, 9 t., eaaz4126.
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
2019
- CyhoeddwydFolic acid and rhodamine labelled pH responsive hyperbranched polymers: Synthesis, characterization and cell uptake studies
Blackburn, C., Tai, H., Salerno, M., Wang, X., Hartsuiker, E. & Wang, W., Tach 2019, Yn: European Polymer Journal. 120, 109259.
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
2018
- CyhoeddwydGenetic Interaction Score (S-Score) Calculation, Clustering, and Visualization of Genetic Interaction Profiles for Yeast.
Roguev, A., Ryan, C. J., Xu, J., Colson, I., Hartsuiker, E. & Krogan, N., Chwef 2018, Yn: Cold Spring Harbor Protocols. 2018, 2
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid - CyhoeddwydGenetic Interaction Screens in Schizosaccharomyces pombe Using the Pombe Epistasis Mapper (PEM) System and a Manual Colony Replicator.
Colson, I. & Hartsuiker, E., Chwef 2018, Yn: Cold Spring Harbor Protocols. 2018, 2
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid - CyhoeddwydHigh-Throughput Quantitative Genetic Interaction Mapping in the Fission Yeast Schizosaccharomyces pombe.
Roguev, A., Ryan, C. J., Hartsuiker, E. & Krogan, N. J., Chwef 2018, Yn: Cold Spring Harbor Protocols. 2018, 2, t. 75-81 7 t.
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
2017
- CyhoeddwydDeoxynucleoside Salvage in Fission Yeast Allows Rescue of Ribonucleotide Reductase Deficiency but Not Spd1-Mediated Inhibition of Replication
Fleck, O., Fahnøe, U., Løvschal, K. V., Gasasira Uwamahoro, M.-F., Marinova, I. N., Kragelund, B. B., Carr, A. M., Hartsuiker, E., Holmberg, C. & Nielsen, O., 25 Ebr 2017, Yn: Genes. 8, 5, 14 t., 128.
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
2015
- CyhoeddwydThe DNA-Binding Domain of S-pombe Mrc1 (Claspin) Acts to Enhance Stalling at Replication Barriers
Zech, J., Godfrey, E. L., Masai, H., Hartsuiker, E. & Dalgaard, J. Z., 22 Gorff 2015, Yn: PLoS ONE. 10, 7
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid - CyhoeddwydUV induced ubiquitination of the yeast Rad4-Rad23 complex promotes survival by regulating cellular dNTP pools
Zhou, Z., Humphryes, N., van Eijk, P., Waters, R., Yu, S. R., Kraehenbuehl, R., Hartsuiker, E. & Reed, S. H., 6 Gorff 2015, Yn: Nucleic Acids Research. 43, 15, t. 7360-7370
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
2011
- CyhoeddwydDetection of covalent DNA-bound Spo11 and topoisomerase complexes
Hartsuiker, E. & Tsubouchi, H. (Golygydd), 28 Ebr 2011, DNA recombination: Methods and Protocols. Springer Science and Business Media LLC, t. 65-77
Allbwn ymchwil: Pennod mewn Llyfr/Adroddiad/Trafodion Cynhadledd › Pennod
2010
- CyhoeddwydCollaborative Action of Brca1 and CtIP in Elimination of Covalent Modifications from Double-Strand Breaks to Facilitate Subsequent Break Repair
Nakamura, K., Kogame, T., Oshiumi, H., Shinohara, A., Sumitomo, Y., Agama, K., Pommier, Y., Tsutsui, K. M., Tsutsui, K., Hartsuiker, E., Ogi, T., Takeda, S. & Taniguchi, Y., 22 Ion 2010, Yn: PLOS Genetics. 6, 1
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid - CyhoeddwydTopoisomerase I regulates open chromatin and controls gene expression in vivo
Durand-Dubief, M., Persson, J., Norman, U., Hartsuiker, E. & Ekwall K., [. V., 7 Gorff 2010, Yn: EMBO Journal. 29, 13, t. 2126 - 2134
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
2009
- CyhoeddwydA supramodular FHA/BRCT-Repeat architecture mediates Nbs1 adaptor function in response to DNA damage.
Lloyd, J., Chapman, J. R., Clapperton, J. A., Haire, L. F., Hartsuiker, E., Li, J., Carr, A. M., Jackson, S. P. & Smerdon, S. J., 2 Hyd 2009, Yn: Cell. 139, 1, t. 100-111
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid - CyhoeddwydCtp1CtIP and Rad32Mre11 nuclease activity are required for Rec12Spo11 removal, but Rec12Spo11 removal is dispensable for other MRN-dependent meiotic functions
Hartsuiker, E., Mizuno, K., Molnar, M., Kohli, J., Ohta, K. & Carr, A. M., Ebr 2009, Yn: Molecular and Cellular Biology. 29, 7, t. 1671-1681 11 t.
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid - CyhoeddwydDistinct Requirements for the Rad32Mre11 Nuclease and Ctp1CtIP in the Removal of Covalently Bound Topoisomerase I and II from DNA
Hartsuiker, E., Neale, M. J. & Carr, A. M., 16 Ion 2009, Yn: Molecular Cell. 33, 1, t. 117-123
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid - CyhoeddwydScreening a genome-wide S.pombe deletion library identifies novel genes and pathways involved in genome stability maintenance.
Deshpande, G. P., Hayles, J., Hoe, K. L., Kim, D. U., Park, H. O. & Hartsuiker, E., 1 Mai 2009, Yn: DNA Repair. 8, 5, t. 672-679
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
2007
- CyhoeddwydTDP1 facilitates repair of ionizing radiation-induced DNA single-strand breaks
El-Khamisy, S. F., Hartsuiker, E. & Caldecott, K. W., 1 Hyd 2007, Yn: DNA Repair. 6, 10, t. 1485-95 11 t.
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
2006
- CyhoeddwydDouble-strand break repair and homologous recombination in Schizosaccharomyces pombe
Raji, H. & Hartsuiker, E., 15 Hyd 2006, Yn: Yeast. 23, 13, t. 963-76 14 t.
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
2005
- CyhoeddwydThe meiotic recombination hot spot ura4A in Schizosaccharomyces pombe
Baur, M., Hartsuiker, E., Lehmann, E., Ludin, K., Munz, P. & Kohli, J., Chwef 2005, Yn: Genetics. 169, 2, t. 551-61 11 t.
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
2004
- CyhoeddwydRoles of histone acetylation and chromatin remodeling factor in a meiotic recombination hotspot
Yamada, T., Mizuno, K.-I., Hirota, K., Kon, N., Wahls, W. P., Hartsuiker, E., Murofushi, H., Shibata, T. & Ohta, K., 21 Ebr 2004, Yn: EMBO Journal. 23, 8, t. 1792-803 12 t.
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
2003
- CyhoeddwydA simple Cre-loxP method for chromosomal N-terminal tagging of essential and non-essential Schizosaccharomyces pombe genes
Werler, P. J. H., Hartsuiker, E. & Carr, A. M., 30 Ion 2003, Yn: Gene. 304, t. 133-41 9 t.
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
2002
- CyhoeddwydA 160-bp palindrome is a Rad50.Rad32-dependent mitotic recombination hotspot in Schizosaccharomyces pombe
Farah, J. A., Hartsuiker, E., Mizuno, K.-I., Ohta, K. & Smith, G. R., Mai 2002, Yn: Genetics. 161, 1, t. 461-8 8 t.
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid - CyhoeddwydA single unbranched S-phase DNA damage and replication fork blockage checkpoint pathway
Marchetti, M. A., Kumar, S., Hartsuiker, E., Maftahi, M., Carr, A. M., Freyer, G. A., Burhans, W. C. & Huberman, J. A., 28 Mai 2002, Yn: Proceedings of the National Academy of Sciences of the United States of America. 99, 11, t. 7472-7 6 t.
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
2001
- CyhoeddwydFission yeast Rad50 stimulates sister chromatid recombination and links cohesion with repair
Hartsuiker, E., Vaessen, E., Carr, A. M. & Kohli, J., 3 Rhag 2001, Yn: EMBO Journal. 20, 23, t. 6660-71 12 t.
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid - CyhoeddwydNovel functional requirements for non-homologous DNA end joining in Schizosaccharomyces pombe
Manolis, K. G., Nimmo, E. R., Hartsuiker, E., Carr, A. M., Jeggo, P. A. & Allshire, R. C., 15 Ion 2001, Yn: EMBO Journal. 20, 1-2, t. 210-21 12 t.
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
1999
- CyhoeddwydThe msh2 gene of Schizosaccharomyces pombe is involved in mismatch repair, mating-type switching, and meiotic chromosome organization
Rudolph, C., Kunz, C., Parisi, S., Lehmann, E., Hartsuiker, E., Fartmann, B., Kramer, W., Kohli, J. & Fleck, O., Ion 1999, Yn: Molecular and Cellular Biology. 19, 1, t. 241-50 10 t.
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
1998
- CyhoeddwydThe role of topoisomerase II in meiotic chromosome condensation and segregation in Schizosaccharomyces pombe
Hartsuiker, E., Bähler, J. & Kohli, J., Hyd 1998, Yn: Molecular Biology of the Cell. 9, 10, t. 2739-50 12 t.
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
1994
- CyhoeddwydImmunocytochemical techniques applied to meiotic chromosomes
Heyting, C., Dietrich, A. J., de Jong, J. H. & Hartsuiker, E., 1994, Chromosome Analysis Protocols. Gosden, J. R. (gol.). Cyfrol 29. t. 287-302 (Methods in Molecular Biology).
Allbwn ymchwil: Pennod mewn Llyfr/Adroddiad/Trafodion Cynhadledd › Pennod › adolygiad gan gymheiriaid
Gweithgareddau
2022
- BU-IIA Funded Project: Genotoxicity of nucleoside analogue anti-viral and anti-cancer drugs
The overall aim of the proposed research is to optimise and apply the range of assays we have developed to assess the genotoxic impact of some key anti-cancer (Gemcitabine) and anti-viral (Remdesivir and Molnupiravir) nucleoside analogues and publish this analysis as proof of principle and advertise the knowledge and expertise we have developed here in Wales. The proposed research involves a new collaboration between Bangor applicants and the recently established company Broken String Biosciences Ltd., which offers assays that are complementary to the assays we have been developing. In the long term, we believe there is significant potential for impact and commercial exploitation of our assays, e.g. by influencing requirements for genotoxic assessment of nucleoside analogue drugs and offering our expertise and novel assays as a commercial service for pharmaceutical companies to assess the on- and off-target effects of candidate nucleoside analogue drugs.
Funding awarded through the Bangor University Innovation and Impact Award (Research Wales Innovation Funding). Value = £45,942
1 Ebr 2022 – 31 Maw 2023
Gweithgaredd: Arall (Cyfrannwr)
Projectau
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Skills & Innovation voucher scheme - Beerobotics - Maxi
01/05/2024 – 31/12/2024 (Wrthi'n gweithredu)
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KESS II MRes with NWCR - BUK2E091
01/10/2022 – 31/03/2024 (Wedi gorffen)
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KESS II Mres with NWCR in Molecular Medicine BUK2231
01/10/2022 – 31/03/2024 (Wedi gorffen)
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KESS II MRes with North West Cancer Research BUK2222
01/01/2021 – 31/01/2022 (Wedi gorffen)
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KESS II MRes with North West Cancer Research BUK2224
01/01/2021 – 31/03/2024 (Wedi gorffen)
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KESS II Phd with Tenovus BUK2E004
01/03/2020 – 31/03/2024 (Wedi gorffen)
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KESS II MRes with North West Cancer Research- BUK2176
01/10/2019 – 31/03/2024 (Wedi gorffen)
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KESS II MRes with North West Cancer Research- BUK2175
01/10/2018 – 01/08/2022 (Wedi gorffen)
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KESS II MRes with North West Cancer Research- BUK2177
01/10/2018 – 31/03/2024 (Wedi gorffen)
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KESS II MRes with North West Cancer Research- BUK2178
01/10/2018 – 31/03/2024 (Wedi gorffen)
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KESS II Phd with Tenovus Cancer Care Ltd- BUK2128
01/11/2017 – 31/03/2024 (Wedi gorffen)
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Quantitative detection of DNA damage and nucleotides using LC/MS/MS
01/01/2016 – 30/04/2016 (Wedi gorffen)
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Genome-wide analysis of topoisomerase removal pathways
01/09/2015 – 01/08/2019 (Wedi gorffen)
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01/04/2015 – 01/08/2019 (Wedi gorffen)
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01/01/2015 – 30/09/2023 (Wedi gorffen)
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Role of Mre11 nuclease activity in replication fork progression
01/11/2014 – 31/10/2015 (Wedi gorffen)
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Role of DNA repair in resisting treatment with Gemcitabine and other analogues
01/01/2014 – 30/06/2017 (Wedi gorffen)
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NWCR Research Fellow in Cancer Biology
23/09/2013 – 01/08/2019 (Wedi gorffen)
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The role of nucleotide excision repair in providing resistance to the nucleoside
01/06/2013 – 10/11/2017 (Wedi gorffen)
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The role of the Mre11 nuclease activity in resistance to cancer drugs
01/12/2011 – 30/11/2013 (Wedi gorffen)
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Genome-wide analysis of topoisomerase removal after camptothecin treatment
01/10/2011 – 31/12/2014 (Wedi gorffen)
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The NISCHR Cancer Genetics Biomedical Research Unit
01/03/2011 – 01/08/2022 (Wedi gorffen)
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01/10/2010 – 30/09/2014 (Wedi gorffen)
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01/09/2010 – 31/08/2016 (Wedi gorffen)